P. Shi

Granzyme B-based CAR T cells block metastasis by eliminating circulating tumor cells

This study develops GrB-CAR T cells targeting mHSP70 to eliminate CTCs and inhibit metastasis in solid tumors.

Aurora Kinase A Inhibition plus Tumor Treating Fields Suppress Glioma Cell Proliferation in a Cilium-Independent Manner

This paper shows that combining Aurora Kinase A inhibition with Tumor Treating Fields reduces glioma cell proliferation, and this effect is not dependent on cilia.

Evolutionary prediction for new echolocators

The paper predicts three new mammalian echolocators using molecular convergence analyses and machine learning, with behavioral experiments confirming echolocation in shrew moles.

High-level production of nervonic acid in the oleaginous yeast Yarrowia lipolytica by systematic metabolic engineering

This study engineered Yarrowia lipolytica to overproduce nervonic acid through metabolic pathway modifications, achieving high titers and purity.

Increasing Ciliary ARL13B Expression Drives Active and Inhibitor-Resistant SMO and GLI into Glioma Primary Cilia

This study shows increased ARL13B expression drives active and inhibitor-resistant SMO and GLI into glioma cilia, promoting treatment resistance.

The specific roles of renal macrophages in monitoring and clearing off intratubular particles

This study identifies the role of renal macrophages in clearing intratubular particles and preventing kidney stone formation through phagocytosis and transmigration.

Tumor Treating Fields Suppression of Ciliogenesis Enhances Temozolomide Toxicity

This study shows TTFields reduce cilia in glioma cells, enhancing TMZ toxicity, and that ciliogenesis timing affects treatment outcomes.

Gene losses may contribute to subterranean adaptations in naked mole-rat and blind mole-rat

This study identifies gene losses in subterranean rodents, showing their potential role in hypoxia tolerance and other adaptations.

Convergent genomic signatures of high altitude adaptation among domestic mammals

This study identifies convergent genomic signatures of high altitude adaptation in domestic mammals by analyzing 327 genomes, revealing positive selection in genes like EPAS1 and C10orf67.