Author

P. Swietach

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

D. Abrahams· 2 shared R. Gillies· 2 shared S. Russell· 2 shared A. E. Hill· 1 shared A. El-Kenawi· 1 shared A. Hulikova· 1 shared A. Ibrahim-Hashim· 1 shared A. Lopez· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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2 shared papersCancer Biology

D. Abrahams

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Solute exchange through gap junctions lessens the adverse effects of inactivating mutations in metabolite-handling genes

S. Monterisi, J. Michl, A. E. Hill, A. Hulikova, G. Abdullayeva, W. F. Bodmer, P. Swietach

The paper shows that gap junction-mediated metabolite exchange rescues functional defects caused by inactivating mutations in metabolite-handling genes in colorectal cancer cells.

bioRxiv · Mar 15, 2022Cancer Biology

Proton export drives the Warburg Effect

S. Russell, L. Xu, Y. Kam, D. Abrahams, B. Ordway, A. Lopez, M. M. Bui, J. Johnson, T. Epstein, E. Ruiz, M. Lloyd, P. Swietach, D. Verduzco, J. Wojtkowiak, R. Gillies

This study shows that proton export drives the Warburg Effect by increasing intracellular alkalization, enhancing glycolytic flux, and promoting cancer aggressiveness.

bioRxiv · Sep 20, 2021 · PreprintCancer Biology

Lymph Nodes Inhibit T-cell Effector Functions Locally by Establishing Acidic Niches

H. Wu, V. Estrella, P. Enriquez-Navas, A. El-Kenawi, S. Russell, D. Abrahams, A. Ibrahim-Hashim, D. Longo, Y. Reshetnyak, K. Luddy, M. Damaghi, S. R. Pillai, M. Beatty, S. Pilon-Thomas, P. Swietach, r. gillies

The paper shows that acidic niches in lymph nodes inhibit T-cell effector functions by blocking lactic acid efflux and reducing glycolysis, keeping T-cells in a state of stasis.

bioRxiv · Jul 2, 2019 · PreprintPhysiology