Author

A. El-Kenawi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Immunology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 3 Research Focus:host-pathogen & immune response· 2 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

J. Dhillon· 3 shared A. Ibrahim-Hashim· 2 shared B. Ruffell· 2 shared K. Luddy· 2 shared r. gillies· 2 shared A. Anderson· 1 shared A. Aydin· 1 shared A. Berglund· 1 shared

Activity by Year

2018-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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3 shared papersCancer Biology

J. Dhillon

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Macrophage-derived cholesterol contributes to therapeutic resistance in prostate cancer

A. El-Kenawi, W. Dominguez-Viqueira, M. Liu, S. Awasthi, A. Keske, K. K. Steiner, L. Noel, J. Dhillon, R. J. Gillies, K. Yamoah, X. Yu, J. Koomen, R. A. Gatenby, B. Ruffell

This study shows that macrophage-derived cholesterol supports androgen biosynthesis in prostate cancer, contributing to resistance to therapy, and that targeting macrophages can enhance treatment outcomes.

bioRxiv · Mar 24, 2021Cancer Biology

Spatial Clustering of CD68+ Tumor Associated Macrophages with Tumor Cells is Associated with Worse Overall Survival in Metastatic Clear Cell Renal Cell Carcinoma

N. H. Chakiryan, G. Kimmel, Y. Kim, A. Hajiran, A. Aydin, L. Zemp, E. Katende, J. Nguyen, N. Lopez-Blanco, J. Chahoud, P. Spiess, M. Fournier, J. Dhillon, L. Wang, C. Moran-Segura, , B. J. Manley

The paper quantifies cellular density and clustering of immune cells in metastatic ccRCC and finds that CD68+ TAM clustering with tumor cells correlates with worse overall survival.

bioRxiv · Jan 4, 2021Cancer Biology

Lymph Nodes Inhibit T-cell Effector Functions Locally by Establishing Acidic Niches

H. Wu, V. Estrella, P. Enriquez-Navas, A. El-Kenawi, S. Russell, D. Abrahams, A. Ibrahim-Hashim, D. Longo, Y. Reshetnyak, K. Luddy, M. Damaghi, S. R. Pillai, M. Beatty, S. Pilon-Thomas, P. Swietach, r. gillies

The paper shows that acidic niches in lymph nodes inhibit T-cell effector functions by blocking lactic acid efflux and reducing glycolysis, keeping T-cells in a state of stasis.

bioRxiv · Jul 2, 2019 · PreprintPhysiology

Acidity promotes tumor progression by altering macrophage phenotype in prostate cancer

A. El-Kenawi, C. Gatenbee, M. Robertson-Tessi, R. Bravo, J. Dhillon, Y. Balagurunathan, A. Berglund, N. Visvakarma, A. Ibrahim-Hashim, J. Choi, K. Luddy, R. Gatenby, S. P. Thomas, A. Anderson, B. Ruffell, R. Gillies

This study shows that tumor acidity promotes prostate cancer by altering macrophage phenotype, both in vitro and in vivo, and is supported by in silico modeling.

bioRxiv · Nov 26, 2018Immunology