Author

A. Ibrahim-Hashim

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Immunology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 3 Research Focus:cancer & tumor microenvironment· 2 Approach:biophysical modeling· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1

Frequent Co-Authors

A. El-Kenawi· 2 shared D. Abrahams· 2 shared K. Luddy· 2 shared M. Damaghi· 2 shared r. gillies· 2 shared R. J. Gillies· 2 shared A. A. Ojeda· 1 shared A. Anderson· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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2 shared papersPhysiology

A. El-Kenawi

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

L-DOS47 enhances response to immunotherapy in pancreatic cancer tumor

B. V. Jardim-Perassi, P. Irrera, D. Abrahams, V. C. Estrella, B. Ordway, S. R. Byrne, A. A. Ojeda, C. J. Whelan, J. Kim, M. S. Beatty, S. Damgaci-Erturk, D. L. Longo, K. J. Gaspar, G. M. Siegers, B. A. Centeno, , A. Ibrahim-Hashim

This study shows that L-DOS47, a urease immunoconjugate, enhances anti-PD1 immunotherapy efficacy in pancreatic cancer by neutralizing tumor acidity.

bioRxiv · Aug 28, 2023 · PreprintCancer Biology

Frequency-dependent interactions determine outcome of competition between two breast cancer cell lines

A. R. Freischel, M. Damaghi, J. J. Cunningham, A. Ibrahim-Hashim, R. J. Gillies, R. A. Gatenby, J. S. Brown

This study shows that competition between two breast cancer cell lines depends on frequency-dependent interactions, not just growth rates or carrying capacities.

bioRxiv · Mar 6, 2020Cancer Biology

Lymph Nodes Inhibit T-cell Effector Functions Locally by Establishing Acidic Niches

H. Wu, V. Estrella, P. Enriquez-Navas, A. El-Kenawi, S. Russell, D. Abrahams, A. Ibrahim-Hashim, D. Longo, Y. Reshetnyak, K. Luddy, M. Damaghi, S. R. Pillai, M. Beatty, S. Pilon-Thomas, P. Swietach, r. gillies

The paper shows that acidic niches in lymph nodes inhibit T-cell effector functions by blocking lactic acid efflux and reducing glycolysis, keeping T-cells in a state of stasis.

bioRxiv · Jul 2, 2019 · PreprintPhysiology

Acidity promotes tumor progression by altering macrophage phenotype in prostate cancer

A. El-Kenawi, C. Gatenbee, M. Robertson-Tessi, R. Bravo, J. Dhillon, Y. Balagurunathan, A. Berglund, N. Visvakarma, A. Ibrahim-Hashim, J. Choi, K. Luddy, R. Gatenby, S. P. Thomas, A. Anderson, B. Ruffell, R. Gillies

This study shows that tumor acidity promotes prostate cancer by altering macrophage phenotype, both in vitro and in vivo, and is supported by in silico modeling.

bioRxiv · Nov 26, 2018Immunology