Author

P. T. Brown

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Cell Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:fluorescence / live-cell microscopy· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:imputation· 2 Approach:Bayesian inference· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Organism:human· 1

Frequent Co-Authors

D. P. Shepherd· 2 shared I. F. Tengganu· 2 shared J. Liu· 2 shared J. M. Murray· 2 shared K. Hu· 2 shared L. F. Arias Padilla· 2 shared R. Kruithoff· 2 shared A. Saurabh· 1 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersBiophysics

D. P. Shepherd

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Author profile →

4 papers

Recent·Most cited

Approaching Maximum Resolution in Structured Illumination Microscopy via Accurate Noise Modeling

A. Saurabh, P. T. Brown, J. S. Bryan, Z. R. Fox, R. Kruithoff, C. Thompson, C. Kural, D. P. Shepherd, S. P. Presse

This paper introduces B-SIM, an unsupervised Bayesian framework for structured illumination microscopy that improves resolution and contrast by accurately modeling noise, outperforming existing methods in both simulated and experimental data.

npj Imaging · Jan 31, 2025Peer-reviewedBiophysics

The cortical microtubules of Toxoplasma gondii underlie the helicity of parasite movement

I. F. Tengganu, L. F. Arias Padilla, J. Munera Lopez, J. Liu, P. T. Brown, J. M. Murray, K. Hu

This study investigates the role of cortical microtubules in Toxoplasma gondii motility, showing that their destabilization reduces helical movement without affecting speed or invasion/egress.

bioRxiv · Apr 23, 2023Cell Biology

An apical protein, Pcr2, is required for persistent movement by the human parasite Toxoplasma gondii

J. M. Lopez, I. F. Tengganu, J. Liu, J. M. Murray, L. F. Arias Padilla, Y. Zhang, P. T. Brown, L. Florens, K. Hu

This study identifies Pcr2 as a critical protein for movement and invasion in Toxoplasma gondii, showing that its absence impairs egress and tissue destruction.

bioRxiv · May 20, 2022Cell Biology

Multicolor structured illumination microscopy and quantitative control of polychromatic coherent light with a digital micromirror device

P. T. Brown, R. Kruithoff, G. J. Seedorf, D. P. Shepherd

This paper develops a method to enable multicolor coherent structured illumination microscopy using a digital micromirror device, overcoming the blazed grating effect and demonstrating improved resolution and signal-to-noise.

bioRxiv · Jul 27, 2020Biophysics