Author

T. Harvey-Samuel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Microbiology· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Organism:Arabidopsis· 2 Approach:experimental assay· 2 Organism:C. elegans· 1 Research Focus:development & morphogenesis· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

L. Alphey· 3 shared D.-K. Purusothaman· 2 shared L. Shackleford· 2 shared C. J. McNamara· 1 shared E. Gonzalez· 1 shared H. White-Cooper· 1 shared J. Martinez· 1 shared J. X. D. Ang· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersMicrobiology

L. Alphey

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Transgenic expression of cif genes from Wolbachia strain wAlbB recapitulates cytoplasmic incompatibility in Aedes aegypti.

C. J. McNamara, T. H. Ant, T. Harvey-Samuel, H. White-Cooper, J. Martinez, L. Alphey, S. P. Sinkins

This study shows that expressing cifA and cifB genes from Wolbachia strain wAlbB in Aedes aegypti testes induces CI-like sterility, which can be rescued by maternal cifA expression.

bioRxiv · Sep 1, 2023 · PreprintMicrobiology

A multiplexed, confinable CRISPR/Cas9 gene drive propagates in caged Aedes aegypti populations

M. A. E. Anderson, E. Gonzalez, M. P. Edgington, J. X. D. Ang, D.-K. Purusothaman, L. Shackleford, K. Nevard, S. A. N. Verkuijl, T. Harvey-Samuel, P. T. Leftwich, K. Esvelt, L. Alphey

The paper tests a CRISPR/Cas9 gene drive in caged Aedes aegypti populations, showing it increases from 50% to 89% carrier frequency despite fitness costs.

bioRxiv · Aug 12, 2022 · PreprintSynthetic Biology

CRISPR/Cas-9 mediated knock-in by homology dependent repair in the West Nile Virus vector Culex quinquefasciatus Say

D.-K. Purusothaman, L. Shackleford, M. Anderson, T. Harvey-Samuel, L. Alphey

This paper demonstrates the first successful germline gene knock-in in Culex quinquefasciatus using CRISPR/Cas9 and homology-dependent repair, achieving a 2.8% transformation rate with a recessive lethal phenotype.

bioRxiv · Jan 14, 2021 · PreprintBioengineering