Author

J. J. Mack

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 2 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

J. P. Kennelly· 3 shared P. Tontonoz· 3 shared A. Ferrari· 2 shared A. H. Bedard· 2 shared E. Whang· 2 shared T. Weston· 2 shared X. Xiao· 2 shared Y. Gao· 2 shared

Activity by Year

2022-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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3 shared papersPhysiology

J. P. Kennelly

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

T cell cholesterol transport is a metabolic checkpoint that links intestinal immune responses to dietary lipid absorption

Y. Gao, J. P. Kennelly, X. Xiao, E. Whang, A. Ferrari, A. H. Bedard, J. J. Mack, A. H. Nguyen, T. Weston, L. F. Uchiyama, M. S. Lee, S. Young, S. J. Bensinger, P. Tontonoz

This study identifies Aster-A as a cholesterol transporter in T cells that regulates immune signaling and metabolic responses by controlling membrane cholesterol levels.

bioRxiv · Mar 8, 2024Physiology

Aster-dependent non-vesicular transport facilitates dietary cholesterol uptake

A. Ferrari, E. Whang, X. Xiao, J. P. Kennelly, B. Romartinez- Alonso, J. J. Mack, T. Weston, K. Chen, Y. Kim, M. Tol, L. Bideyan, A. Nguyen, Y. Gao, L. Cui, A. H. Bedard, , P. Tontonoz

The paper identifies the Aster pathway as critical for dietary cholesterol uptake and shows it can be targeted with a small molecule inhibitor.

bioRxiv · Jul 7, 2023 · PreprintPhysiology

Polarized Mechanosensitive Signaling Domains Protect Arterial Endothelial Cells Against Inflammation

S.-G. Hong, J. W. Ashby, J. P. Kennelly, M. Wu, E. Chattopadhyay, R. Foreman, P. Tontonoz, P. Turowski, M. Gallagher-Jones, J. J. Mack

The paper shows that polarized mechanosensitive domains in endothelial cells mediate anti-inflammatory signaling under high shear stress.

bioRxiv · May 26, 2023 · PreprintCell Biology

The DNA binding protein BCL6 regulates NFκB-controlled endothelial inflammatory gene expression

A. F. Acevedo, J. J. Mack, N. M. Valenzuela

This study shows BCL6 represses NFκB-driven inflammation in cardiac endothelial cells by interacting with NFκB and inhibiting gene expression.

bioRxiv · Nov 3, 2022 · PreprintImmunology