Author

P. V'kovski

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 9 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 9 Research Focus:host-pathogen & immune response· 7 Organism:human· 5 Research Focus:cell type annotation· 3 Research Focus:drug response / drug discovery· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Organism:mouse· 2

Frequent Co-Authors

V. Thiel· 10 shared R. Dijkman· 9 shared N. Ebert· 7 shared A. Kratzel· 6 shared J. Portmann· 6 shared M. Holwerda· 6 shared H. Stalder· 5 shared S. Pfaender· 5 shared

Activity by Year

2018-2021 · peak 8/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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10 shared papersMicrobiology

V. Thiel

Mutual co-authors in cluster

Author profile →

10 papers

Recent·Most cited

A genome-wide CRISPR screen identifies interactors of the autophagy pathway as conserved coronavirus targets

A. Kratzel, J. N. Kelly, Y. Brueggemann, J. Portmann, P. V'kovski, D. Todt, N. Ebert, E. Steinmann, R. Dijkman, G. Zimmer, S. Pfaender, V. Thiel

This study identifies autophagy-related host factors as conserved targets for coronavirus replication using CRISPR screens and shows that immunophilin inhibitors can block viral replication.

bioRxiv · Feb 24, 2021Microbiology

No evidence for human monocyte-derived macrophage infection and antibody-mediated enhancement of SARS-CoV-2 infection

O. Garcia-Nicolas, P. V'kovski, F. Zettl, G. Zimmer, V. Thiel, A. Summerfield

This study shows SARS-CoV-2 and SARS-CoV-1 do not infect human macrophages or induce inflammation, and patient serum does not enhance infection or trigger immune responses in these cells.

bioRxiv · Dec 22, 2020Immunology

Susceptibility of well-differentiated airway epithelial cell cultures from domestic and wildlife animals to SARS-CoV-2

M. Gultom, M. Licheri, L. Laloli, M. Wider, M. Straessle, S. Steiner, A. Kratzel, T. T. N. Thao, H. Stalder, J. Portmann, M. Holwerda, P. V'kovski, N. Ebert, N. Stokar - Regenscheit, C. Gurtner, , R. Dijkman

This study assesses the susceptibility of airway epithelial cell cultures from various animals to SARS-CoV-2, finding efficient replication only in monkey and cat models.

bioRxiv · Nov 10, 2020 · PreprintMicrobiology

LY6E impairs coronavirus fusion and confers immune control of viral disease

S. Pfaender, K. B. Mar, E. Michailidis, A. Kratzel, D. Hirt, P. V'kovski, W. Fan, N. Ebert, H. Stalder, H. Kleine-Weber, M. Hoffmann, H. H. Hoffmann, M. Saeed, R. Dijkman, E. Steinmann, , V. Thiel

This study identifies LY6E as an interferon-induced gene that restricts coronavirus entry and pathogenesis by inhibiting spike protein-mediated fusion and protecting immune cells.

Nature Microbiology · Jul 23, 2020Peer-reviewedMicrobiology

Identification of five antiviral compounds from the Pandemic Response Box targeting SARS-CoV-2

M. Holwerda, P. V'kovski, M. Wider, V. Thiel, R. Dijkman

This study screens 400 compounds from the Pandemic Response Box and identifies five with antiviral activity against SARS-CoV-2, including some more effective than Remdesivir.

bioRxiv · May 17, 2020 · PreprintMicrobiology

Disparate temperature-dependent virus - host dynamics for SARS-CoV-2 and SARS-CoV in the human respiratory epithelium

P. V'kovski, M. Gultom, J. N. Kelly, S. Steiner, J. Russeil, B. Mangeat, E. Cora, J. Pezoldt, M. Holwerda, A. Kratzel, L. Laloli, M. Wider, J. Portmann, T. T. N. Thao, N. Ebert, , R. Dijkman

This study compares temperature-dependent replication and immune response dynamics of SARS-CoV-2 and SARS-CoV in human airway epithelial cells, highlighting differences in their antiviral responses and transmission efficiency.

bioRxiv · Apr 27, 2020Microbiology

Comprehensive single cell analysis of pandemic influenza A virus infection in the human airways uncovers cell-type specific host transcriptional signatures relevant for disease progression and pathogenesis.

J. N. Kelly, L. Laloli, P. V'kovski, M. Holwerda, J. Portmann, V. Thiel, R. Dijkman

This study uses scRNA-seq to analyze IAV infection in human airway epithelial cells, revealing cell-type specific host responses and viral tropism shifts.

bioRxiv · Apr 3, 2020 · PreprintMicrobiology

Efficient inactivation of SARS-CoV-2 by WHO-recommended hand rub formulations and alcohols

A. Kratzel, D. Todt, P. V'kovski, S. Steiner, M. L. Gultom, T. T. N. Thao, N. Ebert, M. Holwerda, J. Steinmann, D. Niemeyer, R. Dijkman, G. Kampf, C. Drosten, E. Steinmann, V. Thiel, S. Pfaender

The paper tests the virucidal activity of WHO-recommended hand rubs and alcohols against SARS-CoV-2, showing efficient inactivation for all tested products.

bioRxiv · Mar 10, 2020 · PreprintMicrobiology

Rapid reconstruction of SARS-CoV-2 using a synthetic genomics platform

T. T. N. Thao, F. Labroussaa, N. Ebert, P. V'kovski, H. Stalder, J. Portmann, J. Kelly, S. Steiner, M. Holwerda, A. Kratzel, M. Gultom, L. Laloli, L. Huesser, M. Wider, S. Pfaender, , V. Thiel

This paper describes a yeast-based synthetic genomics platform for rapid reconstruction of RNA viruses, including SARS-CoV-2, using synthetic DNA fragments and TAR cloning.

bioRxiv · Feb 21, 2020Microbiology

Determination of host cell proteins constituting the molecular microenvironment of coronavirus replicase complexes by proximity-labeling

P. V'kovski, M. Gerber, J. Kelly, S. Pfaender, N. Ebert, S. Braga Lagache, C. Simillion, J. Portmann, H. Stalder, V. Gaschen, R. Bruggmann, M. Stoffel, M. Heller, R. Dijkman, V. Thiel

The paper identifies host proteins near coronavirus replicase complexes using proximity-labeling and shows their roles in viral replication and host processes.

bioRxiv · Sep 14, 2018Microbiology