C1q from C1q+ tumor-associated myeloid cells promotes resistance to T-cell engagers and CAR T-cells and is induced by LIF and glucocorticoids
María López Vázquez, Sergio Espinosa-Gil, Raffaella Iurlaro, Laura Carrillo Bosch, Ariadna Grinyo i Escuer, Dario Solis Sayago, Alexandra Arias, Isabel Cuartas, Almudena Neva-Alejo, Laia Cuesta‐Casanovas, Ester Bonfill‐Teixidor, Cayetano Galera Martinez, Cesar Merino Allona, Maria Duarte Leon, Irepan Salvador‐Martínez, , Joan Seoane
This study identifies C1q from C1q+ tumor-associated myeloid cells as a key immunosuppressive factor in glioblastoma that impairs T-cell engagers and CAR T-cell efficacy, induced by LIF and glucocorticoids.
bioRxiv · Sep 17, 2026 · PreprintCancer Biology