In vivo CRISPR-based screen identifies ZC3H12C as a mediator of CAR-T cell dysfunction in solid tumors
Paula Barbao, Alba Rodríguez-García, Ariel Galindo‐Albarrán, Marta Giménez-Alejandre, Pablo Clavero, Teresa Lobo‐Jarne, Marta Botas, Guillem Colell, Joan Castellsagué, Guim Cascalló, Irene Andreu-Saumell, Marta Soria-Castellano, Salut Colell, Berta Marzal, Beatriz Martín-Mur, , Sònia Guedan
The paper identifies ZC3H12C as a mediator of CAR-T cell dysfunction in solid tumors through an in vivo CRISPR screen and validates its role using single-cell RNA and ATAC-seq.
bioRxiv · May 2, 2026 · PreprintImmunology