Human ESCRT-I and ALIX function as scaffolding helical filaments in vivo
Stephanie J. Spada, Kevin M. Rose, Paola Sette, Sarah K. O’Connor, Vincent Dussupt, V. Siddartha Yerramilli, Kunio Nagashima, Virginie Helle Sjoelund, Phillip Cruz, Juraj Kabát, Sundar Ganesan, Margery G. Smelkinson, Aleksandra Nita‐Lazar, Forrest H. Hoyt, Suzanne Scarlata, , Fadila Bouamr
This study shows ESCRT-I and ALIX form helical filaments in vivo, serving as structural scaffolds and ESCRT-III assembly templates for membrane scission and viral budding.
bioRxiv · May 1, 2024 · PreprintCell Biology