EZHIP constrains Polycomb Repressive Complex 2 activity in germ cells
Roberta Ragazzini, Raquel Pérez-Palacios, Irem H. Baymaz, Seynabou Diop, Katia Ancelin, Dina Zielinski, Audrey Michaud, Maëlle Givelet, Máté Borsos, Setareh Aflaki, Patricia Legoix, Pascal W.T.C. Jansen, Nicolas Servant, Maria‐Elena Torres‐Padilla, Déborah Bourc’his, , Raphaël Margueron
This study identifies EZHIP as a novel cofactor of PRC2 that limits its activity in germ cells, leading to altered H3K27me2/3 deposition and impaired fertility in female mice.
Nature Communications · Aug 26, 2019Peer-reviewedDevelopmental Biology