Máté Borsos

AAV-DJ Enables Targeted Gene Modulation in Human Ovarian Cells

This study demonstrates that AAV-DJ efficiently and safely transduces human ovarian cells, enabling targeted gene modulation with significant knockdown of AMHR2 and TGF{beta}1.

Defining a Midgestational Window for In Utero Genome Editing of the Fetal Murine Cortex

The paper establishes a method for in utero genome editing in fetal mouse cortex at midgestation, demonstrating efficient editing with reduced off-target effects.

Dysregulated mammalian estrus cycle rescued by timed activation of VIP neurons in the circadian pacemaker and late afternoon light exposure

The paper shows that timed activation of VIP neurons in the SCN and late afternoon light exposure can rescue dysregulated estrus cycles in mice.

Mechanism of cell polarisation and first lineage segregation in the human embryo

This study identifies the mechanism of first lineage segregation in human embryos through cell polarisation, showing it occurs at the 8-cell stage via F-actin and Par complex polarisation, with PLC activation and GATA3 regulation.

EZHIP constrains Polycomb Repressive Complex 2 activity in germ cells

This study identifies EZHIP as a novel cofactor of PRC2 that limits its activity in germ cells, leading to altered H3K27me2/3 deposition and impaired fertility in female mice.