Author

Peter T. Mains

Elements Biosciences (United States)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genomics· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:variant calling· 3 Assay:whole-genome sequencing· 3 Organism:human· 2 Assay:scRNA-seq· 1

Frequent Co-Authors

Bryan R. LajoieiD· 3 shared Junhua ZhaoiD· 3 shared Semyon KruglyakiD· 3 shared Adeline Mah· 2 shared Andrew M. BoddickeriD· 2 shared Joshua ChaniD· 2 shared Juan Moreno· 2 shared Kelly N. Wiseman· 2 shared

Activity by Year

2023-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersGenomics

Bryan R. LajoieORCID

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3 papers

Recent·Most cited

A simplified hybrid capture approach retains high specificity and enables PCR-free workflow

Adeline Mah, Xiaodong Qi, Junhua Zhao, Kelly N. Wiseman, Laure Edoli, Kyle S. Metcalfe, Kyle Donohoe, Micah T. Ojeda, Sophie Billings, Juan Moreno, Marina McCowin, Ben Krajacich, Kevin Green, Ramkrishna Adhikary, Andrew M. Boddicker, , Michael J. R. Previte

This paper introduces a simplified hybrid capture method that eliminates PCR and bead-based steps while maintaining specificity and improving variant calling.

BMC Genomics · Sep 2, 2025Peer-reviewedGenomics

FLEXIBLE, PRODUCTION-SCALE, HUMAN WHOLE GENOME SEQUENCING ON A BENCHTOP SEQUENCER

Kevin Green, Benjamin J. Krajacich, Kelly N. Wiseman, Peter T. Mains, Samantha Robertson, Sophie Billings, Marina McCowin, Mitch Sudkamp, Ching Shing Lo, Bryan R. Lajoie, Semyon Kruglyak, Shawn Levy, Junhua Zhao

This paper demonstrates high-quality, scalable human whole-genome sequencing on a benchtop sequencer, achieving 30x coverage with flexibility and cost-effectiveness.

BMC Genomics · Jun 3, 2025Peer-reviewedMolecular Biology

Sequencing by avidity enables high accuracy with low reagent consumption

Sinan Arslan, Francisco J. Garcia, Minghao Guo, Matthew William Kellinger, Semyon Kruglyak, Jake A. LeVieux, Adeline Mah, Haosen Wang, Junhua Zhao, Chunhong Zhou, Andrew Altomare, John Bailey, Matthew B. Byrne, Chiting Chang, Steve X. Chen, , Jordan M. Neysmith

This paper introduces avidity sequencing, a new chemistry that improves sequencing accuracy and reduces reagent use, enabling applications like single-cell RNA-seq and whole-genome sequencing.

Nature Biotechnology · May 25, 2023Peer-reviewedGenomics