Molecular mechanism of the key dormancy regulator DosR-dependent transcription activation in Mycobacterium tuberculosis
Jing Shi, Zhenzhen Feng, Han Fu, Yirong Huang, Liqiao Xu, Qian Song, Wei Chen, Yu Feng, Liang-Dong Lyu, Wei Lin
This study determines the cryo-EM structure of the DosR-dependent transcriptional activation complex in Mtb and identifies its molecular mechanism for dormancy regulation.
bioRxiv · Oct 11, 2025 · PreprintMicrobiology