Author

Wei Chen

Nanjing University of Chinese MedicineORCID 0000-0002-8316-1728Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Wei Chen23 papers · Centre National de la Recherche Scientifique

Biology Disciplines

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Biochemistry· 1 Genomics· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Assay:cryo-EM· 2 Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:database / resource· 1 Organism:E. coli· 1 Assay:fluorescence / live-cell microscopy· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Jing ShiiD· 3 shared Liqiao Xu· 2 shared Qian Song· 2 shared Wei LiniD· 2 shared Yirong HuangiD· 2 shared Yu FengiD· 2 shared Zhenzhen Feng· 2 shared Beining Ma· 1 shared

Activity by Year

2025-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersGenomics

Jing ShiORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Expanded gut microbial genomes from Chinese populations reveal population-specific genomic features related to human physiological traits

Quanbin Dong, Beining Ma, Xiaofeng Zhou, Pan Huang, Mengke Gao, Shuai Yang, Yuwen Jiao, Yan Zhou, Zhun Shi, Qiufeng Deng, Dongxu Hua, Xiuchao Wang, Lu Liu, Chengcheng Zhang, Chuan Zhang, , Lianmin Chen

The paper constructs a comprehensive gut microbiome reference database from Chinese and non-Chinese populations, revealing population-specific microbial features linked to host physiology.

Genome Medicine · Oct 31, 2025Peer-reviewedGenomics

Molecular mechanism of the key dormancy regulator DosR-dependent transcription activation in Mycobacterium tuberculosis

Jing Shi, Zhenzhen Feng, Han Fu, Yirong Huang, Liqiao Xu, Qian Song, Wei Chen, Yu Feng, Liang-Dong Lyu, Wei Lin

This study determines the cryo-EM structure of the DosR-dependent transcriptional activation complex in Mtb and identifies its molecular mechanism for dormancy regulation.

bioRxiv · Oct 11, 2025 · PreprintMicrobiology

Structural insight into the transcription activation mechanism of the phage Mor/C family activators

Jing Shi, Zonghang Ye, Yirong Huang, Liqiao Xu, Simin Xu, Lihong Xie, Wei Chen, Lu Wang, Zhenzhen Feng, Qian Song, Shuang Wang, Yu Feng, Wei Lin

This study presents cryo-EM structures of Mor-TAC and C-TAC complexes, revealing a tetrameric binding mode and interactions with RNAP, elucidating the transcription activation mechanism of phage Mor/C family activators.

bioRxiv · May 2, 2025 · PreprintBiochemistry