Targeting Pregnane X Receptor with a Potent Agonist-Based PROTAC to Delay Colon Cancer Relapse
Lucile Bansard, Guillaume Laconde, Vanessa Delfosse, Tiphaine Huet, Margaux Ayeul, Émilie Rigal, Quentin Donati, Sabine Gerbal‐Chaloin, Martine Daujat‐Chavanieu, Luc Brunel, Baptiste Legrand, Alain Chavanieu, Anthony R. Martin, Julie Pannequin, William Bourguet, , Jean‐Marc Pascussi
This study designs and tests a PXR agonist-based PROTAC (JMV7048) that degrades PXR in cancer cells, reducing chemoresistance and delaying colon cancer relapse.
Oncogenesis · Aug 30, 2025Peer-reviewedCancer Biology