William Bourguet

Structural and evolutionary insights into DAF-12 interactions with transcriptional coactivators in parasitic nematodes

This study investigates DAF-12 interactions with transcriptional coactivators in parasitic nematodes using structural and bioinformatic approaches, revealing conserved and nematode-specific mechanisms of coactivator recruitment.

New structural insights into the control of the retinoic acid receptors RAR/RXR by DNA, ligands and transcriptional coregulators

This study reveals how DNA sequence and ligand binding influence the structural dynamics of RAR/RXR-coregulator complexes through integrative structural analysis.

Targeting Pregnane X Receptor with a Potent Agonist-Based PROTAC to Delay Colon Cancer Relapse

This study designs and tests a PXR agonist-based PROTAC (JMV7048) that degrades PXR in cancer cells, reducing chemoresistance and delaying colon cancer relapse.

Distinct 2-phenyl-imidazo pyridine derivatives drive ER degradation and selectively impair proliferation of ER+ breast cancer cells via the aryl hydrocarbon receptor

The paper identifies X15695 as an AHR ligand that promotes ER degradation and inhibits ER+ breast cancer cell proliferation more effectively than fulvestrant.

Towards accurate high-throughput ligand affinity prediction by exploiting structural ensembles, docking metrics and ligand similarity

The paper develops a method for predicting ligand affinities using structural ensembles and docking metrics, showing improved accuracy when combining structure-based and ligand-based features.