Author

R. A. Barker

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Bioengineering· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Organism:human· 4 Approach:statistical model· 4 Research Focus:differential expression· 3 Assay:bulk RNA-seq· 2 Approach:deep learning· 2 Assay:scRNA-seq· 2 Approach:experimental assay· 1

Frequent Co-Authors

X. He· 4 shared E. Prigmore· 3 shared K. Roberts· 3 shared L. Mamanova· 3 shared M. D. Young· 3 shared M. Haniffa· 3 shared O. Bayraktar· 3 shared A. Piapi· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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4 shared papersCancer Biology

X. He

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Author profile →

4 papers

Recent·Most cited

Single cell transcriptomics reveals chondrocyte differentiation dynamics in vivo and in vitro

J. E. G. Lawrence, S. Woods, K. Roberts, D. N. Sumanaweera, P. Balogh, A. V. Predeus, P. He, T. Li, K. Polanski, E. Prigmore, E. Tuck, L. Mamanova, D. Zhou, S. Webb, L. Jardine, , S. Teichmann

This study uses single-cell transcriptomics to compare in vitro and in vivo chondrocyte differentiation, identifies off-target differentiation, and improves in vitro protocols by inhibiting FOXO1.

bioRxiv · Dec 20, 2023Bioengineering

A spatial human thymus cell atlas mapped to a continuous tissue axis

N. Yayon, V. R. Kedlian, L. Boehme, C. Suo, B. Wachter, R. T. Beuschel, O. Amsalem, K. Polanski, S. Koplev, E. Tuck, E. Dann, J. Van Hulle, S. Perera, T. Putteman, A. V. Predeus, , Tag

The paper maps the spatial organization of the human thymus across developmental stages using a multimodal atlas and identifies key cellular and molecular features of T cell development.

bioRxiv · Oct 25, 2023Immunology

Tumor to normal single cell mRNA comparisons reveal a pan-neuroblastoma cancer cell

G. Kildisiute, W. M. Kholosy, M. D. Young, K. Roberts, R. Elmentaite, S. R. van Hooff, E. Khabirova, A. Piapi, C. Thevanesan, E. Bugallo Blanco, C. Burke, L. Mamanova, P. Lijnzaad, T. Margaritis, F. C. P. Holstege, , S. Behjati

The paper compares tumor and normal single-cell mRNA data to show neuroblastoma cells resemble fetal sympathoblasts across diverse samples.

bioRxiv · Jun 22, 2020Cancer Biology

Cellular mRNA signals in human kidney tumors

M. D. Young, T. J. Mitchell, L. M. Custers, T. Margaritis, F. Morales, K. Kwakwa, E. Khabirova, G. Kildisiute, T. R. Oliver, R. R. d. Krijger, M. M. v. d. Heuvel-Eibrink, F. Comitani, A. Piapi, E. B. Blanco, C. Thevanesan, , Holste

This study analyzes mRNA signals in 1,300 kidney tumors to determine their differentiation state and origin, finding that childhood tumors show fetal signals while most adult tumors do not, with exceptions in certain cancer types.

bioRxiv · Mar 19, 2020Cancer Biology