S. Behjati

Single cell transcriptomics reveals chondrocyte differentiation dynamics in vivo and in vitro

This study uses single-cell transcriptomics to compare in vitro and in vivo chondrocyte differentiation, identifies off-target differentiation, and improves in vitro protocols by inhibiting FOXO1.

Multifocal, multiphenotypic tumours arising from an MTOR mutation acquired in early embryogenesis

The paper traces the origin of four synchronous renal tumours in a child to an early embryonic MTOR mutation, showing its role in tumour development and clinical implications.

Oncogenic RAS-Pathway Activation Drives Oncofetal Reprogramming and Creates Therapeutic Vulnerabilities in Juvenile Myelomonocytic Leukemia

This study identifies oncofetal reprogramming in juvenile myelomonocytic leukemia, linking RAS-pathway activation to fetal gene expression and revealing CD52 as a therapeutic target.

Transcriptional signals of dedifferentiation in human cancer

This study examines dedifferentiation in cancer using single-cell atlases, finding that adult cancers do not revert to an embryonic state but retain foetal signals, while childhood cancers show universal foetal state features.

Integrative analysis of neuroblastoma by single-cell RNA sequencing identifies the NECTIN2-TIGIT axis as a target for immunotherapy

The paper uses single-cell RNA sequencing to analyze neuroblastoma and identifies the NECTIN2-TIGIT axis as a potential target for immunotherapy.

Clonal diversification and histogenesis of malignant germ cell tumours

This study analyzes the genome and transcriptome of 547 GCT histological units to explore clonal diversification and histogenesis, finding unifying genomic and transcriptional features across GCTs.

Poised cell circuits in human skin are activated in disease

The paper creates a single-cell atlas of human skin, showing how cell circuits change in inflammatory diseases like atopic dermatitis and psoriasis.

Tumor to normal single cell mRNA comparisons reveal a pan-neuroblastoma cancer cell

The paper compares tumor and normal single-cell mRNA data to show neuroblastoma cells resemble fetal sympathoblasts across diverse samples.

A cell atlas of human thymic development defines T cell repertoire formation

This study creates a cell atlas of the human thymus using scRNA-seq, revealing new cell populations and insights into T-cell development and TCR recombination.

Single-cell sequencing reveals a clonal expansion of pro-inflammatory synovial CD8 T cells expressing tissue homing receptors in psoriatic arthritis

The paper identifies clonal expansion of pro-inflammatory CD8 T cells in psoriatic arthritis joints using single-cell sequencing and links them to tissue homing receptors and antigen specificity.

A novel innate lymphoid cell delineates childhood autoimmune arthritis

The paper identifies a novel synovial innate lymphoid cell (ILC) subtype associated with a specific type of childhood autoimmune arthritis, highlighting its role in inflammation and potential as a therapeutic target.