Author

A. V. Predeus

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Cell Biology· 2 Bioengineering· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 5 Research Focus:cell type annotation· 4 Approach:experimental assay· 4 Organism:bacteria (other)· 3 Assay:bulk RNA-seq· 3 Approach:deep learning· 3 Research Focus:differential expression· 3 Research Focus:gene regulatory network inference· 3

Frequent Co-Authors

J. C. D. Hinton· 3 shared D. L. Hammarlöf· 2 shared E. Prigmore· 2 shared E. Tuck· 2 shared K. Hokamp· 2 shared K. Polanski· 2 shared L. Lacharme-Lora· 2 shared N. Wenner· 2 shared

Activity by Year

2018-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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3 shared papersMicrobiology

J. C. D. Hinton

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Single cell transcriptomics reveals chondrocyte differentiation dynamics in vivo and in vitro

J. E. G. Lawrence, S. Woods, K. Roberts, D. N. Sumanaweera, P. Balogh, A. V. Predeus, P. He, T. Li, K. Polanski, E. Prigmore, E. Tuck, L. Mamanova, D. Zhou, S. Webb, L. Jardine, , S. Teichmann

This study uses single-cell transcriptomics to compare in vitro and in vivo chondrocyte differentiation, identifies off-target differentiation, and improves in vitro protocols by inhibiting FOXO1.

bioRxiv · Dec 20, 2023Bioengineering

Generation of transplantable and biologically responsive colonic tissue from human induced pluripotent stem cells using a rapid co-differentiation platform.

W. Dalleywater, A. V. Predeus, B. Cakir, P. Mazin, J. Vadakekolathu, S. Rutella, M. L. Meakin, A. A. Ritchie, S. Montazid, S. Cuevas Ocana, N. Holmes, V. Wright, F. Seng, A. Bills, D. Sculthorpe, , M. Ilyas

This paper develops a co-differentiation platform using human iPSCs to generate transplantable colonic tissue that mimics native mucosa and responds to biological signals.

bioRxiv · Dec 8, 2023 · PreprintCell Biology

A spatial human thymus cell atlas mapped to a continuous tissue axis

N. Yayon, V. R. Kedlian, L. Boehme, C. Suo, B. Wachter, R. T. Beuschel, O. Amsalem, K. Polanski, S. Koplev, E. Tuck, E. Dann, J. Van Hulle, S. Perera, T. Putteman, A. V. Predeus, , Tag

The paper maps the spatial organization of the human thymus across developmental stages using a multimodal atlas and identifies key cellular and molecular features of T cell development.

bioRxiv · Oct 25, 2023Immunology

Polybacterial intracellular coinfection of epithelial stem cells in periodontitis

Q. T. Easter, B. F. Matuck, G. B. Stark, C. L. Worth, A. V. Predeus, B. Fremin, K. T. Huynh, V. Ranganathan, D. Pereira, T. Weaver, K. Miller, P. Perez, A. Hasuike, Z. Chen, M. Bush, , K. M. Byrd

This study identifies polybacterial intracellular co-infection in human periodontal epithelial cells, revealing its proinflammatory effects and potential role in chronic diseases.

bioRxiv · Aug 23, 2023 · PreprintCell Biology

Genome-wide fitness analysis identifies genes required for in vitro growth and macrophage infection by African and Global Epidemic pathovariants of Salmonella Enteritidis

W. Y. Fong, R. Canals, A. V. Predeus, B. Perez-Sepulveda, N. Wenner, L. Lacharme-Lora, N. Feasey, P. Wigley, J. C. D. Hinton

This study uses transposon insertion sequencing to identify genes required for growth and macrophage infection in African and Global Epidemic S. Enteritidis, finding shared and strain-specific virulence factors.

bioRxiv · Apr 6, 2022Microbiology

An accessible, efficient and global approach for the large-scale sequencing of bacterial genomes

B. M. Perez-Sepulveda, D. Heavens, C. V. Pulford, A. V. Predeus, R. Low, H. Webster, C. Schudoma, W. Rowe, J. Lipscombe, C. Watkins, B. Kumwenda, N. Shearer, K. Costigan, K. S. Baker, N. A. Feasey, , The 10KSG consortium

The paper describes a low-cost, efficient pipeline for large-scale bacterial genome sequencing, demonstrating its application in collecting and sequencing 10,419 isolates from multiple countries.

Genome Biology · Dec 21, 2021Peer-reviewedMicrobiology

Niche-specific profiling reveals transcriptional adaptations required for the cytosolic lifestyle of Salmonella enterica

L. A. Knodler, T. R. Powers, A. L. Haeberle, D. L. Hammarlöf, J. A. Cundiff, A. V. Predeus, K. Hokamp, J. C. D. Hinton

This study identifies niche-specific transcriptional adaptations in Salmonella enterica for cytosolic and vacuolar lifestyles using RNA-seq and microscopy.

bioRxiv · Jan 11, 2021Microbiology

Adding function to the genome of African Salmonella ST313

R. Canals, D. L. Hammarlöf, C. Kröger, S. V. Owen, W. Y. Fong, L. Lacharme-Lora, X. Zhu, N. Wenner, S. E. Carden, J. Honeycutt, D. M. Monack, R. A. Kingsley, P. Brownridge, R. R. Chaudhuri, W. P. M. Rowe, , J. Hinton

The paper compares genomic and transcriptomic differences between Salmonella ST313 and ST19 isolates to identify phenotypic variations and a novel plasmid maintenance system.

bioRxiv · Oct 22, 2018Microbiology