R. A. Harris

Regionalized cell and gene signatures govern oesophageal epithelial homeostasis

The paper creates a cell atlas of the adult mouse oesophagus, revealing regionalized cell and gene signatures that govern epithelial homeostasis and disease susceptibility.

Galectin-3 Mediates Vascular Dysfunction in Obesity by Regulating NADPH Oxidase 1

This study shows that Galectin-3 deletion improves vascular function in obese mice by reducing NOX1-mediated oxidative stress.

Genome-wide coancestry reveals details of ancient and recent male-driven reticulation in baboons

Genomic data from 225 baboons reveal novel inter-species gene flow sites and local admixture effects across different lineages.

A network of CD163+ macrophages monitors enhanced permeability at the blood-dorsal root ganglion barrier

The paper identifies CD163+ macrophages as key regulators of blood-DRG barrier permeability through caveolar transcytosis and reveals their distinct role in vascular monitoring.

Jagged1 overexpression on T cells induces thymic regulatory T cells leading to thymic involution

This study identifies Jagged1 overexpression in T cells as a driver of thymic involution through increased regulatory T cells, observed in a mouse model with thymic atrophy.

Hibernation shows no apparent effect on germline mutation rates in grizzly bears

This study finds no difference in male mutation bias or per-generation mutation rates between hibernating grizzly bears and non-hibernating species.

Comparative Molecular Genomic Analyses of a Spontaneous Rhesus Macaque Model of Mismatch Repair-Deficient Colorectal Cancer

This study characterizes a spontaneous MMRd CRC model in rhesus macaques, finding high MSI levels and gene expression patterns similar to human CRC, supporting their use as an animal model.

De novo mutations in domestic cat are consistent with an effect of reproductive longevity on both the rate and spectrum of mutations

This study estimates the mutation rate in domestic cats and finds a paternal age effect, suggesting reproductive longevity influences mutation rate and spectrum across species.

Primate phylogenomics uncovers multiple rapid radiations and ancient interspecific introgression

This study uses genome-wide data to resolve primate phylogenetic relationships, identifying multiple radiations and ancient introgression events.

Origins and long-term patterns of copy-number variation in rhesus macaques

This study examines CNV mutation patterns in rhesus macaques, finding low mutation rates, no age correlation, and more segregating deletions than duplications compared to humans.

MHC genotyping from rhesus macaque exome sequences

This study introduces a method to genotype MHC class I and II from rhesus macaque exome sequences with high accuracy, outperforming conventional methods.

Reproductive longevity predicts mutation rates in primates

The paper shows that paternal age determines de novo mutation rates in owl monkeys and proposes a model linking reproductive longevity to mutation rates across primates.