M. J. Tuvim

Antimicrobial mitochondrial reactive oxygen species induction by lung epithelial metabolic reprogramming

The paper shows that CpG ODNs interact with mitochondrial VDAC1 to induce antimicrobial ROS in lung epithelial cells, offering a new therapeutic strategy for pneumonia without antibiotics.

Epithelial Immunomodulation by Aerosolized Toll-like Receptor Agonists Attenuates Allergic Responsiveness in Mice

Aerosolized Toll-like receptor agonists reduce allergic inflammation in mice by modulating airway epithelial cell responses to allergens.

Potentiating TMEM16A channel function has no effect on airway goblet cells or bronchial and pulmonary vascular smooth muscle function

This study tests if modulating TMEM16A channel function affects airway goblet cells or smooth muscle function, finding no significant effects.

Immune modulation to improve survival of respiratory virus infections in mice

The paper shows that Pam2-ODN treatment improves survival in mice infected with a paramyxovirus by reducing viral burden and blocking CD8+ T cell-driven inflammation.

Inducible epithelial resistance improves survival of Sendai virus pneumonia in mice by both inactivating virus and preventing CD8+ T cell-mediated immunopathology

This study shows that Pam2-ODN treatment improves survival in mice with Sendai virus pneumonia by inactivating the virus and reducing CD8+ T cell-mediated inflammation.

Different Munc18 Proteins Mediate Baseline and Stimulated Airway Mucin Secretion

The paper identifies distinct roles of Munc18 isoforms in baseline and stimulated airway mucin secretion, showing Munc18b's protective role in asthma and cystic fibrosis models.

Control of Mast Cell Regulated Exocytosis by Munc13 Proteins

This study identifies Munc13-4 as essential for mast cell regulated exocytosis and IgE-mediated anaphylaxis, while Munc13-2 plays a minor role.