Author

D. Knight

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4 Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Assay:proteomics· 6 Organism:human· 5 Research Focus:cell type annotation· 4 Research Focus:cell signaling & trafficking· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

S. Warwood· 3 shared C. Francavilla· 2 shared C. Jorgensen· 2 shared H. R. Ferguson· 2 shared J. D. Humphries· 2 shared J. Ferguson· 2 shared J. Watson· 2 shared M. C. Jones· 2 shared

Activity by Year

2019-2021 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersCell Biology

S. Warwood

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Spatially Resolved Phosphoproteomics Reveals Fibroblast Growth Factor Receptor Recycling-driven Regulation of Autophagy and Survival

J. Watson, H. R. Ferguson, R. M. Brady, J. Ferguson, P. Fullwood, H. Mo, K. H. Bexley, D. Knight, J.-M. Schwartz, M. P. Smith, C. Francavilla

The paper uses spatially resolved phosphoproteomics to show FGFR2b recycling activates mTOR and ULK1, suppressing autophagy and promoting cell survival in cancer cells.

bioRxiv · Dec 4, 2021Cell Biology

Pancreatic ductal adenocarcinoma cells employ integrin α6β4 to form hemidesmosomes and regulate cell proliferation

J. D. Humphries, J. Zha, J. Burns, J. A. Askari, C. R. Below, M. R. Chastney, M. C. Jones, A. Mironov, D. Knight, D. A. O'Reilly, M. J. Dunne, D. R. Garrod, C. Jorgensen, M. J. Humphries

This study identifies integrin α6β4 and hemidesmosomes as critical for PDAC cell proliferation and ECM organization, with implications for therapeutic targeting.

bioRxiv · Aug 19, 2021Cancer Biology

A secreted proteomic footprint for stem cell pluripotency

P. A. Lewis, E. Silajdzic, H. Smith, N. Bates, C. A. Smith, D. Knight, C. Denning, D. R. Brison, S. J. Kimber

The paper identifies a proteomic signature associated with early loss of pluripotency in human stem cells and demonstrates its diagnostic potential using multiplexed biomarkers.

bioRxiv · Apr 14, 2021Cell Biology

Reciprocal Priming between RTKs at Recycling Endosomes Orchestrates Cellular Signaling Outputs

M. P. Smith, H. R. Ferguson, J. Ferguson, E. Zindy, K. M. Kowalczyk, T. Kedward, C. Bates, J. Parsons, J. Watson, S. Chandler, P. Fullwood, S. Warwood, D. Knight, R. B. Clarke, C. Francavilla

The paper identifies reciprocal priming between FGFRs and EGFR at recycling endosomes that coordinates signaling outputs in breast cancer cells.

bioRxiv · Jan 4, 2021Cell Biology

Definition of the fibroblast adhesome using multiplexed proximity biotinylation

M. R. Chastney, C. Lawless, J. D. Humphries, S. Warwood, M. C. Jones, D. Knight, C. Jorgensen, M. J. Humphries

The paper defines the fibroblast adhesome using multiplexed proximity biotinylation and identifies functional modules within integrin adhesion complexes.

bioRxiv · Jan 24, 2020Cell Biology

Laser capture microdissection coupled mass spectrometry (LCM-MS) for spatially resolved analysis of formalin-fixed and stained human lung tissues

J. A. Herrera, V. Mallikarjun, S. Rosini, M. A. Montero, S. Warwood, R. O'Caulian, D. Knight, M. A. Schwartz, J. Swift

This paper develops an optimized microproteomics method for analyzing H&E-stained FFPE lung tissues, identifying 1252 differentially expressed proteins including 137 ECM proteins.

bioRxiv · Aug 13, 2019Biochemistry