Author

R. C. Gimple

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Organism:human· 2 Research Focus:chromatin & epigenetic regulation· 1 Assay:clinical cohort / trial· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Approach:statistical model· 1

Frequent Co-Authors

J. N. Rich· 2 shared A. E. Clark· 1 shared A. Khan· 1 shared A. M. Armando· 1 shared A. Rzhetsky· 1 shared A. Sen· 1 shared B. C. Prager· 1 shared B. F. Cravatt· 1 shared

Activity by Year

2021-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersCancer Biology

J. N. Rich

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2 papers

Recent·Most cited

Leveraging Allele-Specific Expression for Therapeutic Response Gene Discovery in Glioblastoma.

A. Sen, B. C. Prager, D. Park, Z. Zhu, R. C. Gimple, J. A. Bernatchez, S. Beck, A. E. Clark, J. L. Siqueira-Neto, J. N. Rich, G. P. McVicker

This study identifies genes with allele-specific expression in glioblastoma stem cells, finding SLFN11 loss linked to drug resistance and susceptibility to Zika virus.

bioRxiv · Jun 22, 2021Cancer Biology

Targeting Glioblastoma Signaling and Metabolism with A Re-Purposed Brain-Penetrant Drug

J. Bi, A. Khan, J. Tang, S. Wu, W. Zhang, R. C. Gimple, T. Koga, A. M. Armando, S. Miki, H. Yang, B. Prager, E. J. Curtis, D. A. Wainwright, F. B. Furnari, J. N. Rich, , P. S. Mischel

This study identifies fluoxetine as a potential therapy for glioblastoma by inhibiting SMPD1 and enhancing temozolomide efficacy, with real-world evidence suggesting improved survival.

bioRxiv · Mar 16, 2021Cancer Biology