Pre-conditioning Modifies the Tumor Microenvironment to Enhance Solid Tumor CAR T Cell Efficacy and Endogenous Immunity
J. P. Murad, D. Tilakawardane, A. K. Park, K. T. Kennewick, L. S. Lopez, H. J. Lee, B. J. Gittins, W.-C. Chang, C. P. Tran, C. Martinez, A. M. Wu, R. E. Reiter, T. B. Dorff, S. J. Forman, S. J. Priceman
This study shows that cyclophosphamide pre-conditioning improves CAR T cell efficacy against solid tumors by modifying the immunosuppressive tumor microenvironment without harming normal tissues.
bioRxiv · Nov 18, 2020Immunology