Author

T. B. Dorff

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Assay:flow cytometry· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:imaging· 1 Organism:mouse· 1

Frequent Co-Authors

C. Martinez· 2 shared S. J. Forman· 2 shared S. J. Priceman· 2 shared A. K. Park· 1 shared A. M. Wu· 1 shared B. J. Gittins· 1 shared C. P. Tran· 1 shared D. Tilakawardane· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersImmunology

C. Martinez

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Author profile →

2 papers

Recent·Most cited

PD-L1 blockade restores CAR T cell activity through IFNγ-regulation of CD163+ macrophages

Y. Yamaguchi, J. Gibson, K. Ou, R. H. Ng, V. D. Jonsson, J. C. Zarif, P. P. Lee, X. Wang, C. Martinez, T. B. Dorff, S. J. Forman, S. J. Priceman

This study shows that PD-L1 blockade enhances CAR T cell activity by altering macrophage phenotypes through IFNγ signaling in the tumor microenvironment.

bioRxiv · Jan 25, 2022 · PreprintImmunology

Pre-conditioning Modifies the Tumor Microenvironment to Enhance Solid Tumor CAR T Cell Efficacy and Endogenous Immunity

J. P. Murad, D. Tilakawardane, A. K. Park, K. T. Kennewick, L. S. Lopez, H. J. Lee, B. J. Gittins, W.-C. Chang, C. P. Tran, C. Martinez, A. M. Wu, R. E. Reiter, T. B. Dorff, S. J. Forman, S. J. Priceman

This study shows that cyclophosphamide pre-conditioning improves CAR T cell efficacy against solid tumors by modifying the immunosuppressive tumor microenvironment without harming normal tissues.

bioRxiv · Nov 18, 2020Immunology