V. Helms

Sbh1/Sec61beta is a specific signal peptide receptor within the Sec61 channel

This study identifies Sbh1/Sec61β as a specific signal peptide receptor that recognizes and guides substrates into the Sec61 channel through its cytosolic IDR and conserved regions.

A better brain? Alternative spliced STIM2 in hominoids arises with synapse formation and creates a gain-of-function variant

The paper identifies a unique STIM2 variant in hominoids that enhances SOCE and may contribute to brain complexity evolution.

The ER protein translocation channel subunit Sbh1 controls virulence of Cryptococcus neoformans

This paper shows that Sbh1 in Cryptococcus neoformans regulates virulence by controlling the secretion of virulence factors through the secretory pathway.

ER translocation of suboptimal targeting sequences depends on Sec61β/Sbh1 and its phosphorylation

The paper shows that phosphorylation of Sbh1 regulates ER translocation of proteins with suboptimal targeting sequences by inducing conformational changes.

Proteomics identifies substrates and a novel component in hSnd2-dependent ER protein targeting

The paper identifies substrates and a novel component, hSnd3, in the hSnd2-dependent ER protein targeting pathway through proteomic analysis.

High glucose enhances antigen-independent CTL killing via TRAIL

This study shows high glucose increases TRAIL expression in CTLs, promoting beta cell apoptosis, and identifies metformin and vitamin D as synergistic therapies to mitigate this effect.

Mycolactone enhances the Ca2+ leakage from endoplasmic reticulum by trapping Sec61 translocons in a Ca2+ permeable state

This study shows mycolactone enhances Ca2+ leakage from the ER by trapping Sec61 translocons in a Ca2+ permeable state, leading to ER Ca2+ depletion.

Identification of molecular candidates which regulate calcium-dependent CD8+ T-cell cytotoxicity

The paper identifies four molecular candidates that regulate Ca2+-dependent CD8+ T-cell cytotoxicity through transcriptome analysis and functional assays.

Proteomics identifies signal peptide features determining the substrate specificity in human Sec62/Sec63-dependent ER protein import

Relative Principal Components Analysis: Application to Analyzing Biomolecular Conformational Changes

This paper introduces RPCA to analyze conformational changes in HIV-1 protease upon drug binding, showing it provides a thermodynamic framework for understanding structural dynamics.