Author

R. Fisher

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Immunology· 2

Signature Assays, Organisms & Methods

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Assay:proteomics· 3 Research Focus:cell type annotation· 2 Approach:deep learning· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1

Frequent Co-Authors

B. M. Kessler· 3 shared A. Pinto-Fernandez· 2 shared E. Sezgin· 2 shared R. Heilig· 2 shared S. Davis· 2 shared A. Handel· 1 shared A. K. Jainarayanan· 1 shared A. Kvalvaag· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersBiochemistry

B. M. Kessler

Mutual co-authors in cluster

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4 papers

Recent·Most cited

ABPP-HT* - Deep meets fast for activity-based profiling of deubiquitylating enzymes using advanced DIA mass spectrometry methods

H. B. L. Jones, R. Heilig, S. Davis, R. Fisher, B. M. Kessler, A. Pinto-Fernandez

The paper introduces ABPP-HT*, an improved ABPP method combining high depth and throughput for profiling deubiquitylating enzymes using DIA MS, achieving consistent profiling of 35-40 DUBs with reduced missing values.

bioRxiv · Feb 18, 2022Biochemistry

Synthetic antigen presenting cells reveal the diversity and functional specialisation of extracellular vesicles composing the fourth signal of T cell immunological synapses.

P. F. Cespedes, A. K. Jainarayanan, L. Fernandez-Messina, S. Valvo, D. G. Saliba, A. Kvalvaag, L. Chen, E. Kurz, C. Ganskow, H. Colin-York, M. Fritzsche, P. Yanchun, T. Dong, E. Johnson, J. A. Siller-Farfan, , M. L. Dustin

This study uses synthetic antigen-presenting cells to analyze the composition and functional specialization of extracellular vesicles released during T cell immunological synapses.

bioRxiv · May 29, 2021 · PreprintImmunology

ABPP-HT - high-throughput activity-based profiling of deubiquitylating enzyme inhibitors in a cellular context

H. Jones, R. Heilig, R. Fisher, B. M. Kessler, A. Pinto-Fernandez

This paper introduces ABPP-HT, a high-throughput method for assessing DUB inhibitor selectivity in cells, showing improved efficiency over traditional ABPP.

bioRxiv · Dec 10, 2020Biochemistry

The chaperonin CCT8 controls proteostasis essential for T cell maturation, selection, and function

B. E. Oftedal, S. Maio, A. Handel, M. P. White, D. Howie, S. Davis, N. Prevot, I. A. Rota, M. E. Deadman, B. M. Kessler, R. Fisher, N. S. Trede, E. Sezgin, R. M. Maizels, G. A. Hollander

This study shows that the chaperonin CCT8 is essential for T cell maturation, selection, and function by maintaining proteostasis, and its absence impairs immune protection against helminths.

bioRxiv · Aug 11, 2020Immunology