Author

R. Fragkoudis

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Bioengineering· 1

Signature Assays, Organisms & Methods

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Organism:Arabidopsis· 3 Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Assay:bulk RNA-seq· 1 Approach:genetic perturbation / CRISPR· 1 Organism:mouse· 1 Research Focus:variant calling· 1

Frequent Co-Authors

A. Merits· 3 shared B. Atkinson· 2 shared C. M. Reitmayer· 2 shared E. Levitt· 2 shared L. Alphey· 2 shared S. Basu· 2 shared S. Lumley· 2 shared S. Rooney· 2 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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3 shared papersMicrobiology

A. Merits

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Inhibition of potassium ion channels reduces Semliki Forest virus genome replication

T. Russell, C. O'Brien, D. Gangotia, S. Fulford, R. Kenny, a. Alkhamees, S. Premchand-Branker, R. Fragkoudis, D. Scholz, G. Barry

This study shows that K+ channel inhibitors reduce SFV replication and cytotoxicity in vitro by disrupting an early post-entry step, suggesting potential for antiviral repurposing.

bioRxiv · May 24, 2023 · PreprintMicrobiology

A Zika virus-responsive sensor-effector system in Aedes aegypti

S. Basu, C. M. Reitmayer, S. Lumley, B. Atkinson, M. L. Schade-Weskott, S. Rooney, W. Larner, E. E. Montiel, R. Gutierrez-Lopez, E. Levitt, H. M. Munyanduki, A. M. E. Elrefaey, A. T. Clarke, S. Koit, E. Zusinaite, , L. Alphey

This paper describes a genetic system in Aedes aegypti mosquitoes that selectively eliminates ZIKV-infected individuals to reduce vectorial capacity.

bioRxiv · Feb 6, 2023 · PreprintBioengineering

Fake it to break it: mimicking superinfection exclusion disrupts alphavirus infection and transmission in the yellow fever mosquito Aedes aegypti

C. M. Reitmayer, E. Levitt, S. Basu, B. Atkinson, R. Fragkoudis, A. Merits, S. Lumley, W. Larner, A. V. Diaz, S. Rooney, C. J. E. Thomas, K. von Wyschetzki, K. Rausalu, L. Alphey

The paper demonstrates that mimicking superinfection exclusion in mosquitoes reduces alphavirus replication and transmission.

bioRxiv · Sep 20, 2022 · PreprintMicrobiology

Mosquito saliva sialokinin-dependent enhancement of arbovirus infection through endothelial barrier leakage

D. Lefteri, S. Bryden, M. Pingen, S. Terry, E. Beswick, G. Georgiev, M. Van Der Laan, V. Mastrullo, P. Campagnolo, R. M. Waterhouse, M. Varjak, A. Merits, R. Fragkoudis, S. Griffin, E. Pondeville, C. S. McKimmie

This study identifies sialokinin in Aedes mosquito saliva as a factor that enhances arbovirus infection by reducing endothelial barrier integrity, suggesting it as a therapeutic target.

bioRxiv · Feb 19, 2021Microbiology