T. Luong

Pulsed low-dose-rate radiation (PLDR) reduces the tumor-promoting responses induced by conventional chemoradiation in pancreatic cancer-associated fibroblasts

This study shows that pulsed low-dose-rate radiation combined with chemotherapy shifts pancreatic cancer-associated fibroblasts from tumor-promoting to tumor-suppressing, reducing desmoplasia and improving neoadjuvant therapy.

Trogocytosis of cancer-associated fibroblasts promotes pancreatic cancer growth and immune suppression via phospholipid scramblase anoctamin 6 (ANO6).

This study identifies ANO6-mediated trogocytosis as a mechanism by which CAFs transfer lipids to PDAC cells, promoting tumor growth and immune suppression.

Modeling multiphage-bacteria kinetics to predict phage therapy potency and longevity

This study models phage-bacteria interactions to predict the potency and longevity of phage cocktails against Pseudomonas aeruginosa.

Eribulin normalizes pancreatic cancer-associated fibroblasts by simulating TGFβ inhibition

This study shows eribulin can normalize pancreatic cancer-associated fibroblasts by mimicking TGFβ inhibition, reducing cancer cell survival under stress.

NetrinG1+ cancer-associated fibroblasts generate unique extracellular vesicles that support the survival of pancreatic cancer cells under nutritional stress

This study identifies NetrinG1+ cancer-associated fibroblasts that produce extracellular vesicles supporting pancreatic cancer cell survival under nutrient stress.

Netrin G1 promotes pancreatic tumorigenesis through cancer associated fibroblastdriven nutritional support and immunosuppression

This study identifies Netrin G1 as a promoter of pancreatic ductal adenocarcinoma tumorigenesis by enhancing cancer-associated fibroblast-driven metabolic support and immunosuppression.

Isolation and characterization of bacteriophages that infect Citrobacter rodentium, a model pathogen for investigating human intestinal diseases

The paper isolates and characterizes two new bacteriophages, CrRp3 and CrRp10, that infect Citrobacter rodentium, finding differences in their host range, lytic cycle, and response to hypoxia.

TGFβ in the obese liver mediates conversion of NK cells to a less cytotoxic ILC1-like phenotype

This study shows that TGFβ in obese livers converts NK cells to a less cytotoxic ILC1-like phenotype, which may protect against NAFLD but increase cancer risk.

A genome-wide screen for ER autophagy highlights key roles of mitochondrial metabolism and ER- resident UFMylation

The paper identifies 200 factors involved in human ER-phagy through CRISPRi screening and reveals mitochondrial metabolism and ER-resident UFMylation as key regulators.

A human ex vivo dengue virus neutralization assay identifies priority antibodies and epitopes for vaccines and therapeutics.

This study develops an ex vivo dengue virus neutralization assay using mosquitoes to identify potent human monoclonal antibodies and their epitopes for vaccine and therapeutic development.

Gut microbiota density influences host physiology and is shaped by host and microbial factors

The paper examines factors influencing gut microbiota density across mammals, disease states, and interventions, finding host and microbial factors shape density and impact health.

Microbial Engraftment and Efficacy of Fecal Microbiota Transplant for Clostridium difficile Patients With and Without IBD

This study evaluates FMT efficacy in CDI patients with and without IBD, finding no difference in recurrence rates and showing engraftment depends on IBD treatment, not disease severity.