R. Gaudin

Human MX1 orchestrates the cytoplasmic sequestration of neo-synthesized influenza A virus vRNPs

This study shows human MX1 restricts influenza A virus by sequestering vRNPs in cytoplasmic clusters via dynein and microtubules, reducing viral production.

Targeting monocytic Occludin impairs monocyte transmigration and HIV neuroinvasion

This study shows that monocytic Occludin promotes monocyte transmigration into the CNS and that targeting it with peptides can block HIV neuroinvasion.

LC3B conjugation machinery promotes autophagy-independent HIV-1 entry in CD4+ T lymphocytes

The paper shows HIV-1 uses LC3B conjugation to enhance its entry into CD4+ T cells, independent of autophagy.

Trans-synaptic dwelling of SARS-CoV-2 particles perturbs neural synapse organization and function

The paper shows that SARS-CoV-2 exposure perturbs neural synapse organization and electrical activity by lodging at trans-synaptic interfaces.

Pharmacological perturbation of intracellular dynamics as a SARS-CoV-2 antiviral strategy

This paper identifies RG10 and RG10b as potent antiviral compounds against SARS-CoV-2 by perturbing ER/virus dynamics, with RG10b showing improved stability and efficacy.

Mapping Cell Membrane Organization and Dynamics Using Soft Nano-Imprint Lithography

The paper maps how cell membrane morphology affects mechanics, dynamics, and protein complex organization using a new nano-imprint lithography method.

CRISPR-based bioengineering of the Transferrin Receptor revealed a role for Rab7 in the biosynthetic secretory pathway

The paper uses CRISPR-based bioengineering to study TfR trafficking and identifies Rab7 as an intermediate compartment in the Golgi-to-PM transport of neosynthetic TfR.

Dynamics of Auxilin1 and GAK in clathrin-1 mediated traffic

The paper shows Aux1 and GAK are recruited in transient bursts to clathrin-coated vesicles, with their timing linked to phosphoinositide changes, suggesting a lipid-switch mechanism for uncoating.