Author

C. Goujon

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 8

Signature Assays, Organisms & Methods

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Organism:human· 8 Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 6 Assay:proteomics· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:drug response / drug discovery· 2 Approach:genetic perturbation / CRISPR· 2 Approach:biophysical modeling· 1

Frequent Co-Authors

J. McKellar· 5 shared M. Arnaud-Arnould· 5 shared M. Tauziet· 5 shared O. Moncorge· 5 shared A. L. Chaves Valadao· 4 shared A. Rebendenne· 4 shared B. Bonaventure· 4 shared E. Labaronne· 3 shared

Activity by Year

2020-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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5 shared papersMicrobiology

J. McKellar

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Human MX1 orchestrates the cytoplasmic sequestration of neo-synthesized influenza A virus vRNPs

J. McKellar, F. Garcia de Gracia, C. Aube, A. L. Chaves Valadao, M. Tauziet, M. Arnaud-Arnould, A. Rebendenne, A. Neyret, E. Labaronne, E. P. Ricci, B. Delaval, R. Gaudin, N. Naffakh, S. Gallois-Montbrun, O. Moncorge, C. Goujon

This study shows human MX1 restricts influenza A virus by sequestering vRNPs in cytoplasmic clusters via dynein and microtubules, reducing viral production.

bioRxiv · Feb 22, 2024 · PreprintMicrobiology

The N-terminal domain of MX1 proteins is essential for their antiviral activity against different families of RNA viruses

J. McKellar, M. Arnaud-Arnould, L. Chaloin, M. Tauziet, C. Arpin-Andre, O. Pourcelot, M. Blaise, O. Moncorge, C. Goujon

This study identifies the N-terminal domain of HsMX1 as essential for antiviral activity against IAV and VSV, with a conserved leucine crucial for function.

bioRxiv · May 10, 2022 · PreprintMicrobiology

Extensive uORF translation from HIV-1 transcripts conditions DDX3 dependency for expression of main ORFs and elicits specific T cell immune responses in infected individuals

E. Labaronne, D. Decimo, L. Bertrand, L. Guiguettaz, T. J. Sohier, D. Cluet, V. Vivet-Boubou, C. Dahoui, P. Francois, I. Hatin, O. Lambotte, A. Samri, B. Autran, L. Etienne, C. Goujon, , E. Ricci

The paper characterizes HIV-1 translational landscape, revealing uORF translation and its role in DDX3 dependency and T cell immune responses.

bioRxiv · Apr 29, 2022Microbiology

Pharmacological perturbation of intracellular dynamics as a SARS-CoV-2 antiviral strategy

W. Bakhache, E. Partiot, V. Lucansky, Y. Bare, B. Bonaventure, C. Goujon, C. Bories, M. S. Deffieu, R. Gaudin

This paper identifies RG10 and RG10b as potent antiviral compounds against SARS-CoV-2 by perturbing ER/virus dynamics, with RG10b showing improved stability and efficacy.

bioRxiv · Sep 10, 2021 · PreprintMicrobiology

TMPRSS2 promotes SARS-CoV-2 evasion from NCOA7-mediated restriction

H. Khan, H. Winstone, J. Jimenez-Guardeno, C. Graham, K. Doores, C. Goujon, D. Matthews, A. Davidson, S. Rihn, M. Palmarini, S. Neil, M. Malim

This study shows that NCOA7 restricts SARS-CoV-2 infection by promoting endosomal acidification, and TMPRSS2 or removal of the furin cleavage site reduces this restriction.

bioRxiv · Jul 23, 2021Microbiology

Bidirectional genome-wide CRISPR screens reveal host factors regulating SARS-CoV-2, MERS-CoV and seasonal coronaviruses

A. Rebendenne, P. Roy, B. Bonaventure, A. L. Chaves Valadao, L. Desmarets, Y. Rouille, M. Tauziet, M. Arnaud-Arnould, D. Giovannini, Y. Lee, P. DeWeirdt, M. Hegde, F. Garcia de Gracia, J. McKellar, M. Wencker, , C. Goujon

The paper performs bidirectional CRISPR screens to identify host factors regulating SARS-CoV-2, MERS-CoV, and seasonal coronaviruses, revealing new anti-viral proteins and general coronavirus cofactors.

bioRxiv · May 19, 2021Microbiology

The DEAD box RNA helicase DDX42 is an intrinsic inhibitor of positive-strand RNA viruses

B. Bonaventure, A. Rebendenne, F. Garcia de Gracia, J. McKellar, S. Gracias, E. Labaronne, M. Tauziet, A. L. Chaves Valadao, E. Bernard, L. Briant, N. Gros, W. Djilli, M. Arnaud-Arnould, V. Courgnaud, H. Parrinello, , C. Goujon

This study identifies DDX42 as an intrinsic antiviral inhibitor that restricts HIV-1 and other positive-strand RNA viruses but not negative-strand RNA viruses.

bioRxiv · Oct 28, 2020Microbiology

SARS-CoV-2 replication triggers an MDA-5-dependent interferon production which is unable to efficiently control replication

A. Rebendenne, A. L. Chaves Valadao, M. Tauziet, G. Maarifi, B. Bonaventure, R. Planes, J. McKellar, S. Nisole, M. Arnaud-Arnould, O. Moncorge, C. Goujon

This study shows that SARS-CoV-2 triggers MDA-5-dependent interferon production in human cells, but this response fails to control viral replication.

bioRxiv · Oct 28, 2020Microbiology