Author

R. Ishitani

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:protein structure prediction· 2 Approach:biophysical modeling· 1 Assay:cryo-EM· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:structural biology· 1

Frequent Co-Authors

O. Nureki· 3 shared Y. Lee· 3 shared M. Takemoto· 2 shared T. Nishizawa· 2 shared A. Minoda· 1 shared C. Jin· 1 shared H. Endou· 1 shared K. Hirata· 1 shared

Activity by Year

2017-2019 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersBiochemistry

O. Nureki

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3 papers

Recent·Most cited

Cryo-EM structure of the human L-type amino acid transporter 1 in complex with glycoprotein CD98hc

Y. Lee, P. Wiriyasermkul, C. Jin, L. Quan, R. Ohgaki, S. Okuda, T. Kusakizako, T. Nishizawa, K. Oda, R. Ishitani, T. Yokoyama, T. Nakane, M. Shirouzu, H. Endou, S. Nagamori, , O. Nureki

This paper reports the cryo-EM structure of the human LAT1-CD98hc heterodimer, revealing its architecture and interactions, and maps disease mutations to explain congenital disorders.

bioRxiv · Mar 14, 2019Biochemistry

Free energy landscape for the entire transport cycle of triose-phosphate/phosphate translocator

M. Takemoto, Y. Lee, R. Ishitani, O. Nureki

This study uses molecular dynamics simulations to reveal the free energy landscape and mechanism of the triose-phosphate/phosphate translocator's transport cycle.

bioRxiv · Oct 20, 2017Biophysics

Structure of the triose-phosphate/phosphate translocator reveals the basis of substrate specificity

Y. Lee, T. Nishizawa, M. Takemoto, K. Kumazaki, K. Yamashita, K. Hirata, A. Minoda, S. Nagatoishi, K. Tsumoto, R. Ishitani, O. Nureki

This study determines the crystal structures of TPT bound to substrates, revealing the molecular basis of its strict 1:1 exchange mechanism.

bioRxiv · Aug 18, 2017Biochemistry