S. Nagatoishi

This study investigates the conformational features and interaction mechanisms of a β-hairpin-like CDR-H3 in the VHH antibody Nb8, revealing key residues critical for structural stability and binding to HigB2.

This study investigates how SNPs in the LI-cadherin gene affect cancer metastasis by weakening cell-cell adhesion through reduced homodimerization and altered hydrogen bonding.

This study compares the molecular interactions of the IL-11/IL-11R/gp130 complex with IL-6/IL-6R/gp130, revealing differences in thermodynamics and domain involvement that may explain distinct biological functions.

This study uses lipid nanodiscs and surface plasmon resonance to identify a fragment compound that inhibits MsbA's ATPase activity, suggesting a pathway for developing stronger inhibitors.

This study investigates the binding mechanism between Mint3 and FIH-1, identifying a novel core site and thermodynamic contributions of Mint3's disordered region.

This study determines the crystal structure of LI-cadherin EC1-4 homodimer and shows its unique architecture and noncanonical calcium ion-free linker, revealing the mechanism of homodimerization essential for cell adhesion.

This study determines the crystal structure of human serum albumin bound to dalbavancin, revealing the binding mechanism and structural changes involved.

This study identifies a chemical fragment that modulates the on-rate of P-cadherin dimerization by inhibiting cell adhesion.

This study determines the crystal structures of TPT bound to substrates, revealing the molecular basis of its strict 1:1 exchange mechanism.