Author

R. J. Levy

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 3 Biophysics· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 2 Research Focus:host-pathogen & immune response· 2 Organism:rat· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1 Organism:human· 1

Frequent Co-Authors

G. Ferrari· 3 shared S. J. Stachelek· 3 shared A. M. Krieger· 2 shared A. Zakharchenko· 2 shared I. Fishbein· 2 shared I. S. Alferiev· 2 shared J. B. Grau· 2 shared S. Keeney· 2 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersBiophysics

G. Ferrari

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Hypercholesterolemia aggravates in-stent restenosis in rabbits: a mitigating effect of stent surface modification with CD47-derived peptide

I. Fishbein, V. V. Inamdar, I. S. Alferiev, G. Bratinov, M. M. Zviman, A. Yekhilevsky, C. Nagaswami, K. L. Gardiner, R. J. Levy, S. J. Stachelek

This study shows that hypercholesterolemia worsens in-stent restenosis in rabbits, but coating stents with a CD47-derived peptide reduces this effect by inhibiting inflammation and cell attachment.

bioRxiv · Feb 27, 2023 · PreprintBioengineering

Intraprocedural endothelial cell seeding of arterial stents via biotin/avidin targeting mitigates in-stent restenosis

I. S. Alferiev, B. Hooshdaran, B. B. Pressly, S. J. Stachelek, P. W. Zoltick, M. Chorny, R. J. Levy, I. Fishbein

This paper describes a method to reduce in-stent restenosis by seeding stents with biotin-modified endothelial cells post-deployment, showing a 30% reduction in restenosis in rats.

bioRxiv · May 25, 2022Bioengineering

Deterioration of Glutaraldehyde Crosslinked Heterograft Biomaterials due to Advanced Glycation End Product Formation and Serum Albumin Infiltration

C. A. Rock, S. Keeney, A. Zakharchenko, H. Takano, D. A. Spiegel, A. M. Krieger, G. Ferrari, R. J. Levy

This study investigates how AGE formation and serum albumin infiltration degrade glutaraldehyde crosslinked biomaterials, leading to structural and mechanical deterioration in bioprosthetic heart valves.

bioRxiv · May 28, 2020 · PreprintBiophysics

Inhibition and down regulation of the serotonin transporter contribute to the progression of degenerative mitral regurgitation

R. J. Levy, E. Fitzpatrick, E. Castillero, , H. J. Shukla, , V. V. Inamdar, A. E. Aghali, J. B. Grau, N. Rioux, E. Salvati, S. J. Keeney, I. Nissim, R. C. C. Gorman, L. Rauova, S. J. Stachelek, C. R. Brown, , G. Ferrari

This study investigates how inhibition and downregulation of the serotonin transporter (SLC6A4) contribute to the progression of degenerative mitral regurgitation through enhanced HTR2B signaling.

bioRxiv · Mar 10, 2020 · PreprintPhysiology

Glycation and Serum Albumin Infiltration Contribute to the Structural Degeneration of Bioprosthetic Heart Valves

A. Frasca, Y. Xue, A. P. Kossar, S. Keeney, C. Rock, A. Zakharchenko, M. Streeter, R. C. Gorman, J. B. Grau, I. George, J. E. Bavaria, A. Krieger, D. Spiegel, R. J. Levy, G. Ferrari

This study shows glycation and serum albumin infiltration contribute to structural degeneration of bioprosthetic heart valves through mechanisms observed in both clinical samples and in vitro models.

bioRxiv · Feb 14, 2020Bioengineering