Author

H. Takano

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1 Assay:proteomics· 1 Organism:rat· 1

Frequent Co-Authors

A. Zakharchenko· 2 shared G. Ferrari· 2 shared S. Keeney· 2 shared A. Krieger· 1 shared A. M. Krieger· 1 shared C. A. Rock· 1 shared C. Rock· 1 shared D. A. Spiegel· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersBiochemistry

A. Zakharchenko

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Mitochondrial protein C15ORF48 is a stress-independent inducer of autophagy that regulates oxidative stress and autoimmunity

Y. Takakura, M. Machida, N. Terada, Y. Katsumi, S. Kawamura, K. Horie, M. Miyauchi, T. Ishikawa, N. Akiyama, T. Seki, T. Miyao, M. Hayama, R. Endo, H. Ishii, Y. Maruyama, , N. Yamaguchi

This study identifies C15ORF48 as a mitochondrial protein that induces stress-independent autophagy, reducing oxidative stress and autoimmunity in thymic epithelial cells.

bioRxiv · Oct 17, 2023Cell Biology

Inhibition of advanced glycation end product formation and serum protein infiltration in bioprosthetic heart valve leaflets: Investigations of anti-glycation agents.

A. Zakharchenko, C. Rock, T. Thomas, S. Keeney, E. Hall, H. Takano, A. Krieger, G. Ferrari, R. Levy

This study investigates anti-AGE agents' effects on AGE and serum protein infiltration in bioprosthetic heart valves using in vitro and in vivo models, finding that PYR significantly inhibits AGE and serum albumin accumulation.

bioRxiv · Feb 28, 2022 · PreprintBiochemistry

Deterioration of Glutaraldehyde Crosslinked Heterograft Biomaterials due to Advanced Glycation End Product Formation and Serum Albumin Infiltration

C. A. Rock, S. Keeney, A. Zakharchenko, H. Takano, D. A. Spiegel, A. M. Krieger, G. Ferrari, R. J. Levy

This study investigates how AGE formation and serum albumin infiltration degrade glutaraldehyde crosslinked biomaterials, leading to structural and mechanical deterioration in bioprosthetic heart valves.

bioRxiv · May 28, 2020 · PreprintBiophysics