C. R. Brown

Environmental context, parameter sensitivity and structural sensitivity impact predictions of annual-plant coexistence

The paper evaluates how environmental context, parameter sensitivity, and model structure affect predictions of species coexistence in annual plants.

A conserved ribosomal protein has entirely dissimilar structures in different organisms

The paper shows that the ribosomal protein msL1/msL2 has conserved location but entirely different structures across species, suggesting evolutionary fold switching driven by changes in rRNA binding sites.

Ribosomes as molecular thermometers: metal-binding sites in ribosomal proteins are robust indicators of bacterial adaptation to heat and cold

The paper identifies temperature-adaptive residues in ribosomal proteins that can estimate bacterial optimal growth temperatures using minimal genomic data.

Robust and durable prophylactic protection conferred by RNA interference in preclinical models of SARS-CoV-2

This study identifies two siRNA combinations that provide robust prophylactic protection against SARS-CoV-2 in hamsters by reducing viral load and preventing lung pathology.

Gosha: a database of organisms with defined optimal growth temperatures

Gosha is a database that compiles optimal growth temperatures for 25,324 species, enabling studies of molecular adaptations to temperature variations.

'Lose-to-gain' adaptation to genome decayin the structure of the smallest eukaryotic ribosomes

This study uses cryo-EM and evolutionary analysis to show how E. cuniculi ribosomes adapt to genome decay through structural innovations that enable extreme rRNA reduction without losing ribosome function.

Inhibition and down regulation of the serotonin transporter contribute to the progression of degenerative mitral regurgitation

This study investigates how inhibition and downregulation of the serotonin transporter (SLC6A4) contribute to the progression of degenerative mitral regurgitation through enhanced HTR2B signaling.