Author

S. Keeney

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4 Cell Biology· 4 Bioengineering· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 9 Organism:mouse· 4 Research Focus:development & morphogenesis· 3 Research Focus:protein structure prediction· 3 Research Focus:cell type annotation· 2 Research Focus:chromatin & epigenetic regulation· 2 Approach:deep learning· 2 Organism:yeast· 2

Frequent Co-Authors

A. Zakharchenko· 3 shared G. Ferrari· 3 shared K. Liu· 3 shared A. Krieger· 2 shared A. Toth· 2 shared C. Rock· 2 shared H. Takano· 2 shared J. Lange· 2 shared

Activity by Year

2017-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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3 shared papersBiochemistry

A. Zakharchenko

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10 papers

Recent·Most cited

Seeding the meiotic DNA break machinery and initiating recombination on chromosome axes

I. Dereli, V. Telychko, F. Papanikos, K. Raveendran, J. Xu, M. Boekhout, M. Stanzione, B. Neuditschko, N. S. Imjeti, E. Selezneva, H. T. Erbasi, S. Demir, T. Giannattasio, M. Gentzel, M. Stevense, , A. Toth

The paper identifies IHO1-HORMAD1 as essential for seeding the meiotic DSB machinery on chromosome axes, ensuring sufficient DSBs for homologous chromosome pairing in mice.

bioRxiv · Nov 27, 2023Cell Biology

Cryo-EM structure of the Spo11 core complex bound to DNA

Y. Yu, J. Wang, K. Liu, Z. Zheng, M. Arter, C. C. Bouuaert, S. Pu, D. J. Patel, S. Keeney

The paper reports cryo-EM structures of Spo11 core complexes bound to DNA, revealing DNA-binding specificity and structural variation in homologs.

bioRxiv · Oct 31, 2023Biochemistry

Structure and DNA bridging activity of the essential Rec114-Mei4 trimer interface

K. Liu, E. M. Grasso, S. Pu, D. Eliezer, S. Liu, S. Keeney

This paper reports the structural model of the Rec114-Mei4 trimer interface and its DNA bridging activity, showing its role in meiotic DSB formation.

bioRxiv · Jan 18, 2023Biochemistry

Inhibition of advanced glycation end product formation and serum protein infiltration in bioprosthetic heart valve leaflets: Investigations of anti-glycation agents.

A. Zakharchenko, C. Rock, T. Thomas, S. Keeney, E. Hall, H. Takano, A. Krieger, G. Ferrari, R. Levy

This study investigates anti-AGE agents' effects on AGE and serum protein infiltration in bioprosthetic heart valves using in vitro and in vivo models, finding that PYR significantly inhibits AGE and serum albumin accumulation.

bioRxiv · Feb 28, 2022 · PreprintBiochemistry

Structures of core eukaryotic protein complexes

I. R. Humphreys, J. Pei, M. Baek, A. Krishnakumar, I. Anishchenko, S. R. Ovchinnikov, J. Zheng, T. Ness, S. Banjade, S. R. Bagde, V. Stancheva, X. Li, K. Liu, Z. Zheng, D. Barerro, , D. Baker

The paper uses coevolution analysis and deep learning to model core eukaryotic protein complexes in yeast, identifying 104 new assemblies and structurally characterizing 608 previously unknown complexes.

bioRxiv · Sep 30, 2021Biochemistry

Deterioration of Glutaraldehyde Crosslinked Heterograft Biomaterials due to Advanced Glycation End Product Formation and Serum Albumin Infiltration

C. A. Rock, S. Keeney, A. Zakharchenko, H. Takano, D. A. Spiegel, A. M. Krieger, G. Ferrari, R. J. Levy

This study investigates how AGE formation and serum albumin infiltration degrade glutaraldehyde crosslinked biomaterials, leading to structural and mechanical deterioration in bioprosthetic heart valves.

bioRxiv · May 28, 2020 · PreprintBiophysics

Glycation and Serum Albumin Infiltration Contribute to the Structural Degeneration of Bioprosthetic Heart Valves

A. Frasca, Y. Xue, A. P. Kossar, S. Keeney, C. Rock, A. Zakharchenko, M. Streeter, R. C. Gorman, J. B. Grau, I. George, J. E. Bavaria, A. Krieger, D. Spiegel, R. J. Levy, G. Ferrari

This study shows glycation and serum albumin infiltration contribute to structural degeneration of bioprosthetic heart valves through mechanisms observed in both clinical samples and in vitro models.

bioRxiv · Feb 14, 2020Bioengineering

Cyclin B3 promotes APC/C activation and anaphase I onset in oocyte meiosis

M. E. Karasu, N. Bouftas, S. Keeney, K. Wassmann

This study identifies cyclin B3's role in promoting APC/C activation and anaphase I onset in mouse oocyte meiosis, showing its essential function in meiotic progression.

bioRxiv · Aug 14, 2018Cell Biology

ATR is a multifunctional regulator of male mouse meiosis

A. Widger, S. K. Mahadevaiah, J. Lange, E. ElInati, J. Zohren, T. Hirota, M. Stanzione, O. Ojarikre, V. Maciulyte, D. de Rooij, A. Toth, S. Keeney, J. M. Turner

This study identifies ATR as a multifunctional regulator of male mouse meiosis by showing its roles in synapsis, recombination, and chromosome axis maintenance.

bioRxiv · Sep 15, 2017Cell Biology

ATR Is Required To Complete Meiotic Recombination In Mice

S. Pacheco, A. Maldonado-Linares, M. Marcet-Ortega, C. Rojas, A. Martinez-Marchal, J. Fuentes-Lazaro, J. Lange, M. Jasin, S. Keeney, O. Fernandez-Capetillo, M. Garcia-Caldes, I. Roig

This study shows ATR is essential for meiotic recombination and prophase completion in mice by promoting RAD51/DMC1 assembly and synapsis.

bioRxiv · May 3, 2017Cell Biology