S. Nakano

NR4A3 deficiency ameliorates contact hypersensitivity and exacerbates psoriasis by regulating gene expression in dendritic cells

This study shows NR4A3 deficiency reduces contact hypersensitivity but worsens psoriasis by altering dendritic cell gene expression.

Prolonged airway explant culture enables study of health, disease, and viral pathogenesis

This study develops methods to culture human and animal airway explants for at least 14 days, preserving tissue architecture and enabling study of health, disease, and viral infection.

Horizontal transmission of penicillin binding protein 1A caused a nationwide spread of β-lactam resistance in pneumococci

The paper traces the nationwide spread of β-lactam resistance in pneumococci through horizontal transmission of a specific PBP1A variant, highlighting its role in resistance emergence.

Isolation and characterization of bacteriophages against IMP-6-producing Klebsiella pneumoniae isolated from clinical settings in Japan

The paper isolates and characterizes 29 bacteriophages against IMP-6-producing Klebsiella pneumoniae from Japan, showing broad host ranges and demonstrating the effectiveness of a phage cocktail in delaying phage-resistant bacteria emergence.

A model of persistent post SARS-CoV-2 induced lung disease for target identification and testing of therapeutic strategies

This paper develops a murine model of persistent post-SARS-CoV-2 lung disease to identify therapeutic targets and test interventions for PASC.

A method for identifying environmental stimuli and genes responsible for genotype-by-environment interactions from a large-scale multi-environment data set

This paper introduces a method to identify environmental stimuli and genes involved in genotype-by-environment interactions using large-scale multi-environment data.

Comparison of 12 molecular detection assays for SARS-CoV-2

The paper compares 12 SARS-CoV-2 molecular assays using respiratory samples, finding some have 100% specificity and high sensitivity, with recommendations for use with internal controls.