Author

R. J. Youle

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4 Biochemistry· 1

Signature Assays, Organisms & Methods

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Organism:human· 5 Research Focus:cell signaling & trafficking· 3 Approach:experimental assay· 3 Assay:proteomics· 2 Approach:biophysical modeling· 1 Research Focus:cell type annotation· 1 Assay:CRISPR screen· 1 Approach:deep learning· 1

Frequent Co-Authors

C. Wang· 2 shared G. kanfer· 2 shared M. E. Ward· 2 shared S. A. Sarraf· 2 shared A. C. Borgeaud· 1 shared A. L. Yokom· 1 shared A. Werner· 1 shared E. Dominguez-Martin· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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2 shared papersBiochemistry

C. Wang

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Author profile →

5 papers

Recent·Most cited

STING induces HOIP-mediated synthesis of M1 ubiquitin chains to stimulate NFkB signaling

T. D. Fischer, E. N. Bunker, P.-P. Zhu, F. Le Guerroue, M. Hadjian, E. Dominguez-Martin, F. Scavone, R. E. Cohen, T. Yao, Y. Wang, A. Werner, R. J. Youle

This study shows STING activates NFkB signaling via HOIP-mediated M1 ubiquitin chains on Golgi membranes, independent of LC3B lipidation.

bioRxiv · Oct 14, 2023 · PreprintCell Biology

Image-based pooled whole genome CRISPR screening for Parkin and TFEB subcellular localization

G. kanfer, S. A. Sarraf, Y. Maman, H. Baldwin, K. R. Johnson, M. E. Ward, M. Kampmann, J. Lippincott-Schwartz, R. J. Youle

The paper introduces AI-Photoswitchable Screening (AI-PS) to identify genes affecting subcellular localization, validating factors involved in TFEB relocation.

bioRxiv · Jul 2, 2020Cell Biology

ULK complex organization in autophagy by a C-shaped FIP200 N-terminal domain dimer

X. Shi, A. L. Yokom, C. Wang, L. N. Young, R. J. Youle, J. H. Hurley

The paper identifies the C-shaped dimeric structure of FIP200's N-terminal domain and its role in organizing the ULK complex by directly binding ATG13.

bioRxiv · Mar 19, 2020Biochemistry

Selective autophagic clearance of protein aggregates is mediated by the autophagy receptor, TAX1BP1

S. A. Sarraf, H. V. Shah, G. Kanfer, M. E. Ward, R. J. Youle

This study identifies TAX1BP1 as a key autophagy receptor mediating selective clearance of protein aggregates, including polyQ proteins, through autophagy.

bioRxiv · Mar 9, 2019 · PreprintCell Biology

Molecular and topological reorganizations in mitochondrial architecture interplay during Bax-mediated steps of apoptosis

N. R. Ader, P. C. Hoffmann, I. Ganeva, A. C. Borgeaud, C. Wang, R. J. Youle, W. Kukulski

This study investigates how Bax activity affects mitochondrial structure during apoptosis, revealing molecular and topological changes that contribute to outer membrane rupture.

bioRxiv · Aug 1, 2018Cell Biology