M. W. Kirschner

Membrane potential mediates the cellular response to mechanical pressure

This study shows that membrane potential mediates cellular responses to mechanical pressure by regulating cell growth, proliferation, and elimination through Hippo and MAPK pathways.

Bacterial cell wall biosynthesis is controlled by growth rate dependent modulation of turgor pressure in E. coli

This study shows that turgor pressure in E. coli increases with growth rate and directly controls cell wall biosynthesis rate.

Beyond G1/S regulation: How cell size homeostasis is tightly controlled throughout the cell cycle?

This study shows cell mass homeostasis is maintained throughout the cell cycle, not just at G1/S, using ceQPM to measure dry mass in mammalian cells.

Protein and Lipid Mass Concentration Measurement in Tissues by Stimulated Raman Scattering Microscopy

The paper introduces NoRI, a SRS microscopy method to measure protein, lipid, and water concentrations in tissues, showing cell-specific variations and disease-related changes in Alzheimer's models.

Lack of Age-related Respiratory Changes in Daphnia

The paper examines age-related changes in respiration rates, lactate/pyruvate ratio, and mitochondrial membrane potential in Daphnia magna, finding no significant age-related changes except for a possible peak in mitochondrial membrane potential in specific tissues.

"Smart Tanks": An Intelligent High-Throughput Intervention Testing Platform in Daphnia

The paper introduces a platform for high-throughput intervention testing in Daphnia magna, using machine learning to estimate phenotypic age under pharmacological perturbations.

Non-canonical open reading frames encode functional proteins essential for cancer cell survival

The paper identifies non-canonical open reading frames (ORFs) that encode functional proteins essential for cancer cell survival, with one example, GREP1, showing preferential essentiality in breast cancer.

YAP independently regulates cell size and population growth dynamics via non-cell autonomous mediators

This study shows YAP regulates cell size and population growth through separate non-cell autonomous mechanisms, with CYR61 mediating growth but not size.

Cell size sensing in animal cells coordinates growth rates and cell cycle progression to maintain cell size uniformity

The paper shows cells adjust growth rates and cell cycle progression to maintain uniform size by sensing their own size and modifying growth and division timing.

Size uniformity of animal cells is actively maintained by a p38 MAPK-dependent regulation of G1-length

The p38 MAPK pathway coordinates cell growth and cell cycle progression by lengthening G1 in small cells, allowing them more time to grow before their next division.

Conformational landscape of the p28-bound human proteasome regulatory particle

The paper determines the cryo-EM structure of the human proteasome regulatory particle bound to p28, revealing its dynamic conformational landscape and role in proteasome assembly.