R. Ketteler

ATG5 is dispensable for ATG8ylation of cellular proteins

The paper investigates the mechanism of protein ATG8ylation, showing that ATG5 is dispensable for this process, unlike its role in lipid ATG8ylation.

Development of the ULK1-Recruiting Chimeras (ULKRECs) to enable proximity-induced and ULK1-dependent degradation of mitochondria

This paper introduces ULK1-Recruiting Chimeras (ULKRECs) that induce ULK1-dependent mitophagy, showing efficacy in Parkinson's fibroblasts independent of the PRKN/PINK axis.

Cardiac glycosides restore autophagy flux in an iPSC-derived neuronal model of WDR45 deficiency

This study identifies cardiac glycosides that restore autophagy and gene expression in an iPSC model of WDR45 deficiency, suggesting potential therapeutic applications for BPAN.

Proximity interactome of LC3B in normal growth conditions

The paper identifies 407 proteins interacting with LC3B in normal growth conditions using APEX2 proteomics, revealing novel interactors and expanding understanding of LC3B's roles beyond autophagy.

Modulation of endothelial organelle size as an antithrombotic strategy

The paper identifies human-licenced drugs that reduce endothelial secretory granule size, offering potential antithrombotic compounds by modulating VWF adhesive activity.

High-content screening for rare respiratory diseases: readthrough therapy in primary ciliary dyskinesia

The paper develops a high-content screening method using differentiated respiratory epithelium from PCD patients to evaluate readthrough therapies for rare respiratory diseases.

Signalling involving MET and FAK supports cell division independent of the activity of the cell cycle-regulating CDK4/6 kinases

This study shows that MET/FAK signaling can activate CDK2 independently of CDK4/6, leading to cell division, and suggests targeting MET/FAK could enhance CDK4/6 inhibitor therapies.