S. Ellis

Discovery and Synthesis of GS-7682, a Novel Prodrug of a 4'-CN-4-Aza-7,9-Dideazaadenosine C-Nucleoside with Broad-Spectrum Potency Against Pneumo- and Picornaviruses and Efficacy in RSV-Infected African Green Monkeys.

This paper describes the discovery and synthesis of GS-7682, a prodrug with broad antiviral activity against RSV and other viruses, showing efficacy in RSV-infected monkeys.

Menopause has not evolved as a general trait in mammals: A response to "Do mammals have menopause?"

The paper critiques a previous study claiming menopause is widespread in mammals, showing its methodology is flawed and concluding menopause is rare.

High-resolution metabolite imaging: luteolinidin accumulates at the host-cyanobiont interface during cold-acclimation in Azolla symbioses

The paper investigates metabolite changes during cold acclimation in Azolla symbioses, finding that luteolinidin accumulates at the host-cyanobiont interface.

Group size modulates kinship dynamics and selection on social traits

This study shows that group size affects kinship dynamics and age-related social behaviors in social mammals, with smaller groups promoting more extreme helping/harming behaviors, especially in younger individuals.

Socioecological drivers of injuries in female and male rhesus macaques (Macaca mulatta)

The paper examines how group size and sex ratios affect injury risk in male and female rhesus macaques, finding sex-specific patterns linked to competition and aggression.

Biomimetic robots reveal flexible adjustment of sexual signalling in a wild invertebrate.

This study uses a biomimetic robot to test if fiddler crabs adjust their waving behavior in response to rival signals, finding no change in rate but longer bouts and altered burrow behavior.

Bayesian inference of toothed whale lifespans

This study develops a Bayesian mortality model to estimate lifespans and age-specific mortality in toothed whales using age-structured data from mass-strandings and other sources.

The emergence of goblet inflammatory or ITGB6hi nasal progenitor cells determines age-associated SARS-CoV-2 pathogenesis

The study identifies age-related differences in nasal epithelial cell responses to SARS-CoV-2 infection, showing distinct progenitor cell dynamics in children and elderly.

Limb Specific Failure of Proliferation and Translation in the Mesenchyme Leads to Skeletal Defects in Diamond Blackfan Anemia

This study identifies site-specific skeletal defects in DBA by showing limb-specific mesenchymal stem cell proliferation and translation failures linked to WNT signaling and p53.

Isomeric lipid signatures reveal compartmentalised fatty acid metabolism in cancer

This study uses stable-isotope labelled fatty acids to reveal distinct metabolic fates of exogenous and de novo synthesized fatty acids in cancer cells, showing compartmentalized lipid metabolism.

Development of a pest threshold decision support system for minimising damage to winter wheat from wheat bulb fly, Delia coarctata

This paper develops two predictive models and a decision support system to manage wheat bulb fly infestations in winter wheat by improving population predictions and assessing crop tolerance.

Sphingolipid Control of Fibroblast Heterogeneity Revealed by Single-Cell Lipidomics

This study identifies sphingolipid composition as a driver of fibroblast heterogeneity and state transitions using single-cell lipidomics and transcriptomics.

Common datastream permutations of animal social network data are not appropriate for hypothesis testing using regression models

The paper shows that common datastream permutations are not suitable for testing regression models in animal social networks due to high false-positive rates.

Targeting RNA Polymerase I transcription synergises with TOP1 inhibition in potentiating the DNA damage response in high-grade serous ovarian cancer

This study identifies that combining RNA Polymerase I inhibitor CX-5461 with TOP1 inhibitor topotecan enhances DNA damage response and efficacy in high-grade serous ovarian cancer.

Inhibition of RNA Polymerase I Transcription Activates Targeted DNA Damage Response and Enhances the Efficacy of PARP Inhibitors in High-Grade Serous Ovarian Cancer

This study shows CX-5461, an RNA polymerase I inhibitor, enhances PARP inhibitor efficacy in HR-deficient HGSOC by inducing replication stress and DNA damage, overcoming resistance mechanisms.