Author

R. Maizels

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Biophysics· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:host-pathogen & immune response· 2 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1 Approach:deep learning· 1

Frequent Co-Authors

D. Smyth· 2 shared A. Diez-Sanchez· 1 shared A. Mukundan· 1 shared A. P. Hinck· 1 shared A. Rossi· 1 shared B. Zhang· 1 shared C. Bertoli· 1 shared C. Huard· 1 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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2 shared papersImmunology

D. Smyth

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Metabolic regulation by prostaglandin E2 impairs lung group 2 innate lymphoid cell responses

C. Robb, Y. Zhou, J. Felton, B. Zhang, M. Goepp, P. Jheeta, D. Smyth, R. Breyer, S. Narumiya, H. McSorley, R. Maizels, J. Schwarze, A. Rossi, C. Yao

This study identifies that PGE2-EP2 signaling suppresses lung ILC2 responses and eosinophilic inflammation, while EP4 agonism restricts these responses, offering potential therapeutic targets for asthma and NERD.

bioRxiv · Dec 23, 2021Immunology

Active growth signalling promotes cancer cell sensitivity to the CDK7 inhibitor ICEC0942

G. Wilson, G. Sava, K. Vuina, C. Huard, L. Meneguello, J. Coulombe-Huntington, T. Bertomeu, R. Maizels, J. Lauring, M. Tyers, S. Ali, C. Bertoli, R. A. M. de Bruin

This study identifies active mTOR signaling and cell growth as predictors of cancer cell sensitivity to the CDK7 inhibitor ICEC0942.

bioRxiv · Sep 10, 2021 · PreprintCancer Biology

Structure-based mapping of the TβRI and TβRII receptor binding sites of the parasitic TGF-β mimic, Hp-TGM

A. Mukundan, C.-H. Byeon, C. S. Hinck, D. Smyth, R. Maizels, A. P. Hinck

This paper identifies the receptor binding sites of the parasitic TGF-β mimic Hp-TGM using biophysical methods, showing it binds to TβRI and TβRII through specific domains.

bioRxiv · Dec 8, 2020 · PreprintBiophysics

Developmental pathways regulate cytokine-driven effector and feedback responses in the intestinal epithelium

H. T. Lindholm, N. Parmar, C. L. Drurey, J. L. Ostrop, A. Diez-Sanchez, R. Maizels, M. J. Oudhoff

The paper investigates how cytokines regulate intestinal epithelial responses through developmental pathways, showing IL-13 induces goblet cells via NOTCH signaling and uses BMP signaling as a feedback loop in tuft cell hyperplasia.

bioRxiv · Jun 19, 2020Immunology