N. Kadri

Identification of GTF2IRD1 as a novel transcription factor essential for acute myeloid leukemia

This study identifies GTF2IRD1 as a novel transcription factor essential for AML cell survival and disease progression, with potential therapeutic implications.

Control of NK cell tolerance in MHC class I-deficiency by regulated SHP-1 localization to the activating immune synapse

The paper shows that SHP-1 localization in NK cell synapses regulates tolerance in MHC class I-deficient cells through transcriptional and spatial mechanisms.

FOXO dictates initiation of B cell development and myeloid restriction in common lymphoid progenitors

The paper shows that FOXO1 and FOXO3 are essential for B cell development and myeloid restriction in common lymphoid progenitors, with their combined loss causing developmental block and loss of B cell lineage.

Systems analysis shows a role of cytophilic antibodies in shaping innate tolerance to malaria

The paper investigates how prior malaria exposure influences immune responses, identifying a role for cytophilic antibodies and FcγRIII+ monocytes in reducing inflammation and promoting disease tolerance.

PD-1 expression on NK cells can be related to cytokine stimulation and tissue residency

The paper investigates PD-1 expression on NK cells, showing its association with tumor-infiltrating NK cells and altered phenotypes in PD-1-deficient mice.

FOXO1 and FOXO3 cooperatively regulate innate lymphoid cell development

This study identifies FOXO1 and FOXO3 as cooperative regulators of innate lymphoid cell development and maturation, affecting lineage specification and response to IL-15.

Tuning antiviral CD8 T-cell response via proline-altered peptide ligand vaccination

This paper shows that modifying peptides with proline can restore CD8 T-cell recognition of viral escape variants, enhancing vaccine effectiveness against immune evasion.