Author

J. B. McPhee

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Assay:proteomics· 3 Research Focus:gene regulatory network inference· 2 Organism:bacteria (other)· 1 Organism:C. elegans· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

Y. H. Cho· 2 shared A. Haller· 1 shared A. Windemuth· 1 shared B. Wang· 1 shared C. H. Choy· 1 shared C. N. Antonescu· 1 shared D. S. Redka· 1 shared E. Ospina-Escobar· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersCell Biology

Y. H. Cho

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4 papers

Recent·Most cited

Salmonella actively modulates TFEB in murine macrophages in a growth-phase and time-dependent manner

S. Inpanathan, E. Ospina-Escobar, V. C. Li, Z. Adamji, T. Lackraj, Y. H. Cho, N. Porco, C. H. Choy, J. B. McPhee, R. J. Botelho

This study shows Salmonella modulates TFEB in macrophages depending on its growth phase and infection time, with stationary-phase Salmonella delaying TFEB nuclear mobilization while late-log Salmonella allows TFEB activation.

Microbiology Spectrum · Jan 11, 2024Peer-reviewedCell Biology

A mutation in the pmrD gene of Shigella flexneri abrogates functional PhoPQ-PmrD-PmrAB signaling and polymyxin B resistance

J. B. McPhee, R. Huynh

The paper identifies a frameshift mutation in the pmrD gene of S. flexneri that disrupts PhoPQ-PmrD-PmrAB signaling and polymyxin B resistance, contrasting with S. sonnei's functional PmrD.

bioRxiv · Jul 26, 2021 · PreprintMicrobiology

Multiscale interactome analysis coupled with off-target drug predictions reveals drug repurposing candidates for human coronavirus disease

M. Sugiyama, H. Cui, D. S. Redka, M. Karimzadeh, E. Rujas, H. Maan, S. Hayat, K. Cheung, R. Misra, J. B. McPhee, R. D. Viirre, A. Haller, R. Botelho, R. Karshafian, S. A. Sabatinos, , C. N. Antonescu

bioRxiv · Apr 13, 2021Cell Biology

Conserved regulation of omptin proteases by the PhoPQ two-component regulatory system in Enterobacteriaceae.

Y. H. Cho, M. R. Fadle Aziz, T. Sutradhar, J. Bashal, V. Cojocari, J. B. McPhee

The paper shows that PhoPQ regulates omptin proteases in Enterobacteriaceae, with conserved binding sites and differential substrate activity among E. coli omptins.

bioRxiv · Feb 28, 2020 · PreprintMicrobiology