Author

R. Paulmurugan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Bioengineering· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell type annotation· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:differential expression· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

A. Chiang· 1 shared A. Krishnan· 1 shared A. Szeglowski· 1 shared A. Telichko· 1 shared C. D. Herickhoff· 1 shared D. Guiggey· 1 shared E. Robinson· 1 shared H. Maecker· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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1 shared paperBioengineering

A. Chiang

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Author profile →

5 papers

Recent·Most cited

Restoration of the Lost Human Beta Defensin (hBD-1) in Cancer as a Strategy to Improve the Efficacy of Chemotherapy

R. S. Pandurangi, R. Paulmurugan, S. Tillai

This study shows that restoring hBD-1 in TNBC cells activates apoptosis pathways, sensitizing them to chemotherapy and reducing tumor volume in a mouse model.

bioRxiv · Apr 3, 2023 · PreprintCancer Biology

Enkurin: A novel marker for myeloproliferative neoplasms from platelet, megakaryocyte, and whole blood specimens.

M. S. Sumanth, Y. Liu, J. Wu, L. Fechter, K. Murugesan, H. Maecker, J. Gotlib, J. Zehnder, R. Paulmurugan, A. Krishnan

The paper identifies enkurin as a novel marker of myeloproliferative neoplasms (MPNs) through analysis of platelet, megakaryocyte, and whole blood specimens, showing inverse association with CDC20 and involvement of calcium homeostasis and ER stress.

bioRxiv · Jan 7, 2023Cancer Biology

FOXA1/2 depletion drives global reprogramming of differentiation state and metabolism in a human liver cell line and inhibits differentiation of human stem cell-derived hepatic progenitor cells

I. T. Warren, D. Guiggey, A. Chiang, M. H. Maloy, O. Ogoke, T. S. Groth, T. Mon, S. Meamardoost, X. Liu, S. Thompson, A. Szeglowski, R. Thompson, P. Chen, R. Paulmurugan, M. L. Yarmush, , N. Parashurama

This study shows that depletion of FOXA1/2 in human liver cells reprograms differentiation state and metabolism, promoting de-differentiation and pluripotency.

bioRxiv · Jun 1, 2020Bioengineering

Ultrasound- and microbubble-mediated targeted delivery of therapeutic microRNA-loaded nanocarriers to deep liver and kidney tissues in pigs

T. di Ianni, R. J. C. Bose, U. K. Sukumar, S. Bachawal, H. Wang, A. Telichko, C. D. Herickhoff, E. Robinson, S. Baker, J. G. Vilches-Moure, S. A. Felt, S. S. Gambhir, R. Paulmurugan, J. D. Dahl

This study validates a platform for ultrasound and microbubble-mediated delivery of microRNA-loaded nanocarriers to deep liver and kidney tissues in pigs, showing enhanced delivery and no tissue damage.

bioRxiv · Jun 3, 2019Bioengineering

A Priori Activation of Apoptosis Pathways of Tumor (AAAPT) Technology: Development of Targeted Apoptosis Initiators for Cancer Treatment .

Raghu S Pandurangi, R. Paulmurugan

This paper introduces AAAPT technology, which sensitizes cancer cells to chemotherapy by activating apoptosis pathways and inhibiting survival pathways, improving treatment efficacy and reducing toxicity.

bioRxiv · Dec 10, 2018Cancer Biology