Author

R. Perez-Jimenez

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Evolutionary Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:protein folding & dynamics· 3 Research Focus:host-pathogen & immune response· 2 Approach:mechanistic / dynamical model· 1 Approach:microscopy & imaging analysis· 1 Assay:protein sequence· 1 Assay:protein structure· 1

Frequent Co-Authors

D. De Sancho· 3 shared A. Reifs· 2 shared J. A. Gavira· 2 shared A. Briceno· 1 shared A. Diaz· 1 shared A. Fernandez· 1 shared A. Fernandez-Calvo· 1 shared A. Fernandez-Trasancos· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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3 shared papersBiophysics

D. De Sancho

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

The Strongest Protein Binder is Surprisingly Labile

A. Fernandez-Calvo, A. Reifs, L. Saa, A. L. Cortajarena, D. De Sancho, R. Perez-Jimenez

The paper investigates the mechanical strength of ClfA, a bacterial adhesin, and finds it is not inherently strong without its human target.

bioRxiv · Feb 18, 2024Biophysics

Evolution of CRISPR-associated Endonucleases as Inferred from Resurrected Proteins

B. Alonso-Lerma, Y. Jabalera, M. Morin, A. Fernandez, S. Samperio, A. Quesada-Ganuza, A. Reifs, S. Fernandez-Penalver, Y. Benitez, L. Soletto, J. A. Gavira, A. Diaz, W. Vranken, B. P. Kleinstiver, A. Sanchez-Mejias, , R. Perez-Jimenez

This study resurrects ancient CRISPR-Cas9 nucleases to show their greater flexibility in PAM and gRNA requirements and their evolution toward double-strand break activity.

bioRxiv · Mar 30, 2022Evolutionary Biology

Conserved cysteines in titin sustain the mechanical function of cardiomyocytes

E. Herrero-Galan, F. Dominguez, I. Martinez-Martin, C. Sanchez-Gonzalez, N. Vicente, L. Lalaguna, E. Bonzon-Kulichenko, E. Calvo, E. Gonzalez-Lopez, M. Cobo-Marcos, B. Bornstein, A. Briceno, J. P. Ochoa, J. M. Garcia-Aznar, C. Suay-Corredera, , Aleg

The paper identifies that mutations in conserved titin cysteines disrupt mechanoredox control, leading to dilated cardiomyopathy in humans.

bioRxiv · Sep 5, 2020Physiology

Coarse-grained molecular simulations of the binding of the SARS-CoV 2 spike protein RBD to the ACE2 receptor

D. De Sancho, R. Perez-Jimenez, J. A. Gavira

This study uses coarse-grained molecular simulations to investigate the dynamic binding of SARS-CoV-2 spike protein RBD to ACE2, finding an all-or-none binding mechanism with significant dynamics in the bound state.

bioRxiv · May 7, 2020 · PreprintBiophysics

Reversible two-state folding of the ultrafast protein gpW under mechanical force

J. Schoenfelder, D. De Sancho, R. Berkovich, R. B. Best, V. Munoz, R. Perez-Jimenez

This study uses single-molecule AFM to show that the ultrafast protein gpW folds and unfolds stochastically under mechanical force, revealing a force-induced folding barrier.

bioRxiv · May 5, 2018Biophysics