Author

G. S. Budinger

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 7 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:mouse· 6 Assay:bulk RNA-seq· 5 Research Focus:cell type annotation· 5 Research Focus:differential expression· 5 Research Focus:cell signaling & trafficking· 3 Research Focus:cell-cell communication· 3 Research Focus:development & morphogenesis· 3

Frequent Co-Authors

A. V. Misharin· 7 shared H. Abdala-Valencia· 6 shared L. Sichizya· 5 shared Z. LuiD· 5 shared A. C. McQuattie-Pimentel· 4 shared C. J. Gottardi· 4 shared N. Joshi· 4 shared N. S. Markov· 4 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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7 shared papersImmunology

A. V. Misharin

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Author profile →

8 papers

Recent·Most cited

Expansion of profibrotic monocyte-derived alveolar macrophages in patients with persistent respiratory symptoms and radiographic abnormalities after COVID-19

J. I. Bailey, C. H. Puritz, K. J. Senkow, N. S. Markov, E. Diaz, E. Jonasson, Z. Yu, S. Swaminathan, Z. Lu, S. Fenske, R. A. Grant, H. Abdala-Valencia, R. J. Mylvaganam, J. Miller, R. I. Cumming, , M. A. Sala

The paper identifies profibrotic monocyte-derived alveolar macrophages and neutrophil recruitment as drivers of lung fibrosis in patients with persistent respiratory symptoms and radiographic abnormalities after COVID-19.

bioRxiv · Jul 30, 2023Immunology

Lung injury induces alveolar type 2 cell hypertrophy and polyploidy with implications for repair and regeneration

A. Weng, M. Maciel-Herrerias, S. J. Watanabe, A. S. Flozak, L. Welch, R. P. Aillon, R. Grant, S. Han, L. Dada, M. HInchcliff, A. Misharin, G. S. Budinger, C. J. Gottardi

This study shows lung injury induces alveolar type 2 cell hypertrophy and polyploidy, which can be reduced by inhibiting the integrated stress response.

American Journal of Respiratory Cell and Molecular Biology · May 1, 2022Peer-reviewedCell Biology

Alveolitis in severe SARS-CoV-2 pneumonia is driven by self-sustaining circuits between infected alveolar macrophages and T cells

R. A. Grant, L. Morales-Nebreda, N. S. Markov, S. Swaminathan, E. R. Guzman, D. A. Abbott, H. K. Donnelly, A. Donayre, I. A. Goldberg, Z. M. Klug, N. Borkowski, Z. Lu, H. Kihshen, Y. Politanska, L. Sichizya, , The NU SCRIPT Study Investigators

The paper identifies a positive feedback loop between SARS-CoV-2-infected alveolar macrophages and T cells in severe COVID-19 patients, driving persistent alveolitis.

Nature · Jan 11, 2021Peer-reviewedImmunology

Influenza-induced activation of recruited alveolar macrophages during the early inflammatory phase drives lung injury and lethality

C. M. Koch, K. Anekalla, Y.-S. Hu, J. M. Davis, M. Ciesielski, G. Gadhvi, S.-Y. Chen, M. Turner, Y. Cheng, B. M. Coates, H. Abdala-Valencia, P. A. Reyfman, A. V. Misharin, G. S. Budinger, D. R. Winter, K. M. Ridge

This study identifies vimentin's role in driving pro-inflammatory responses in alveolar macrophages during influenza infection, linking it to lung injury and mortality.

bioRxiv · Jun 8, 2020 · PreprintImmunology

Resetting proteostasis with ISRIB prevents pulmonary fibrosis

S. Watanabe, N. S. Markov, Z. Lu, R. Piseaux Aillon, S. Soberanes, C. E. Runyan, Z. Ren, R. A. Grant, M. Maciel, H. Abdala-Valencia, Y. Politanska, K. Nam, L. Sichizya, H. G. Kihshen, N. Joshi, , A. V. Misharin

ISRIB reduces pulmonary fibrosis severity in young and old mice by modulating stress response signaling in alveolar epithelial cells.

bioRxiv · Feb 26, 2020 · PreprintImmunology

Single-cell RNA-seq reveals spatially restricted multicellular fibrotic niches during lung fibrosis

N. Joshi, S. Watanabe, R. Verma, R. P. Jablonski, C.-I. Chen, P. Cheresh, P. A. Reyfman, A. C. McQuattie-Pimentel, L. Sichizya, A. S. Flozak, C. J. Gottardi, C. M. Cuda, H. Perlman, M. Jain, D. W. Kamp, , A. V. Misharin

The paper identifies monocyte-derived alveolar macrophages as causally linked to fibrosis in lung tissue through autocrine signaling and fibroblast activation.

European Respiratory Journal · Jan 1, 2020Peer-reviewedImmunology

Impaired phagocytic function in CX3CR1+ tissue-resident skeletal muscle macrophages prevents muscle recovery after influenza A virus-induced pneumonia in aged mice

C. E. Runyan, L. C. Welch, E. Lecuona, M. Shigemura, L. Amarelle, H. Abdala-Valencia, N. Joshi, Z. Lu, K. Nam, N. S. Markov, A. C. McQuattie-Pimentel, R. Piseaux-Aillon, Y. Politanska, L. Sichizya, S. Watanabe, , A. V. Misharin

bioRxiv · Nov 7, 2019Immunology

The Aging Microenvironment Shapes Alveolar Macrophage Identity in Aging

A. C. McQuattie-Pimentel, Z. Ren, N. Joshi, S. Watanabe, T. Stoeger, M. Chi, Z. Lu, L. Sichizya, R. Piseaux, C.-I. Chen, S. Soberanes, P. A. Reyfman, J. M. Walter, K. R. Anekalla, J. M. Davis, , G. S. Budinger

This study shows that the aging lung microenvironment shapes alveolar macrophage identity, influencing their phenotype during aging and after injury.

bioRxiv · Jul 29, 2019 · PreprintImmunology